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The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin

de Sousa, J.P. ; Carvalho, R.G. ; Barbosa-Martins, L.F. ; Torquato, R.J.S. ; Mugnol, K.C.U. ; Nascimento, F.D. ; Tersariol, I.L.S. ; Puppin-Rontani, R.M.

Journal of dental research, 2019-03, Vol.98 (3), p.347-354 [Periódico revisado por pares]

Los Angeles, CA: SAGE Publications

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  • Título:
    The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin
  • Autor: de Sousa, J.P. ; Carvalho, R.G. ; Barbosa-Martins, L.F. ; Torquato, R.J.S. ; Mugnol, K.C.U. ; Nascimento, F.D. ; Tersariol, I.L.S. ; Puppin-Rontani, R.M.
  • Assuntos: Atomic force microscopy ; Collagen ; Collagen (type I) ; Crystals ; Dental caries ; Dentin ; Dentistry ; Fibers ; Fluorides ; Hydroxyapatite ; Mechanical properties ; Microscopy ; Peptides ; Proteolysis ; Remineralization ; Surface plasmon resonance ; Tissue engineering
  • É parte de: Journal of dental research, 2019-03, Vol.98 (3), p.347-354
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The major goal in restorative dentistry is to develop a true regenerative approach that fully recovers hydroxyapatite crystals within the caries lesion. Recently, a rationally designed self-assembling peptide P11-4 (Ace-QQRFEWEFEQQ-NH2) has been developed to enhance remineralization on initial caries lesions, yet its applicability on dentin tissues remains unclear. Thus, the present study investigated the interaction of P11-4 with the organic dentin components as well as the effect of P11-4 on the proteolytic activity, mechanical properties of the bonding interface, and nanoleakage evaluation to artificial caries-affected dentin. Surface plasmon resonance and atomic force microscopy indicated that P11-4 binds to collagen type I fibers, increasing their width from 214 ± 4 nm to 308 ± 5 nm (P < 0.0001). P11-4 also increased the resistance of collagen type I fibers against the proteolytic activity of collagenases. The immediate treatment of artificial caries-affected dentin with P11-4 enhanced the microtensile bonding strength of the bonding interface (P < 0.0001), reaching values close to sound dentin and decreasing the proteolytic activity at the hybrid layer; however, such effects decreased after 6 mo of water storage (P < 0.05). In conclusion, P11-4 interacts with collagen type I, increasing the resistance of collagen fibers to proteolysis, and improves stability of the hybrid layer formed by artificial caries-affected dentin.
  • Editor: Los Angeles, CA: SAGE Publications
  • Idioma: Inglês
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