Idioma:

The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C

Oliveira, Arthur Ivan N ; Malta, Fernanda M ; Zitelli, Patricia Momoyo Y ; Salles, Ana Paula M ; Gomes-Gouvea, Michele S ; Nastri, Ana Catharina S ; Pinho, Joao Renato R ; Carrilho, Flair J ; Oliveira, Claudia P ; Mendes-Corrêa, Maria Cássia ; Pessoa, Mario G ; Mazo, Daniel F

BMC gastroenterology, 2021-02, Vol.21 (1), p.81-81, Article 81 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C
Autor: Oliveira, Arthur Ivan N ; Malta, Fernanda M ; Zitelli, Patricia Momoyo Y ; Salles, Ana Paula M ; Gomes-Gouvea, Michele S ; Nastri, Ana Catharina S ; Pinho, Joao Renato R ; Carrilho, Flair J ; Oliveira, Claudia P ; Mendes-Corrêa, Maria Cássia ; Pessoa, Mario G ; Mazo, Daniel F
Assuntos: Aged ; Alanine ; Alanine transaminase ; Alcohol ; Alkaline phosphatase ; Blood pressure ; Body mass index ; Brazil ; Cholesterol ; Complications and side effects ; Cross-Sectional Studies ; Deoxyribonucleic acid ; Development and progression ; Diabetes ; DNA ; Enzymes ; Ethnicity ; Fatty liver ; Fibrosis ; Gastroenterology ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genetic variation ; Genotype ; Health care ; Hepatitis B ; Hepatitis C ; Hepatitis C virus ; Hepatitis C, Chronic - genetics ; Hepatitis C, Chronic - pathology ; Hepatitis virus ; Histology ; Humans ; Infections ; Inflammation ; Insulin resistance ; Interferon ; Lipase - genetics ; Liver - pathology ; Liver Cirrhosis - genetics ; Liver Cirrhosis - pathology ; Liver diseases ; Membrane Proteins - genetics ; Metabolic diseases ; Metabolic syndrome ; Non-alcoholic Fatty Liver Disease - genetics ; Non-alcoholic Fatty Liver Disease - pathology ; Obesity ; Patients ; Polymorphism, Single Nucleotide ; Population ; Regression analysis ; Risk factors ; Serum levels ; Statistical analysis ; Steatosis ; Triglycerides ; Variables
É parte de: BMC gastroenterology, 2021-02, Vol.21 (1), p.81-81, Article 81
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Despite the growing body of knowledge about TM6SF2 and PNPLA3 polymorphisms in non-alcoholic fatty liver disease, their influence in the spectrum of HCV liver disease is not yet fully defined. Besides that, admixed populations, such as Brazilians, were not included in most of the studies. This cross-sectional study enrolled 365 treatment-naïve patients with HCV and 134 healthy individuals. TM6SF2 (rs58542926 c.499C > T) and PNPLA3 (rs738409 c.444C > G) polymorphisms were evaluated regarding their association with clinical and laboratory data, histological liver steatosis and fibrosis, and with components of the metabolic syndrome. In HCV subjects, the frequencies of TM6SF2 CC and CT + TT were 89% and 11%, while PNPLA3 frequencies of CC and CG + GG were 51.4% and 48.6%. In the univariate logistic regression analysis, the TM6SF2 CT + TT genotype in HCV was associated with significant liver fibrosis (p = 0.047; OR 1.953; 95% CI 1.009-3.788). In comparison to the CT + TT genotype, the TM6SF2 CC genotype in HCV was associated with older age (p = 0.002), higher frequency of arterial hypertension (p = 0.032), obesity (p = 0.030), metabolic syndrome (p = 0.014) and lower total cholesterol levels (p = 0.036). The PNPLA3 GG subjects had lower body mass index than CG/ CC individuals (p = 0.047). None of the polymorphisms, or their combinations, was independently associated with hepatic steatosis or fibrosis. On the other hand, older age, lower serum levels of total cholesterol, and higher serum levels of alanine aminotransferase and alkaline phosphatase were associated with liver fibrosis in the multivariate logistic regression analysis. In this evaluation of an admixed HCV population, neither TM6SF2 nor PNPLA3 polymorphisms were independently associated with hepatic steatosis or fibrosis. Other factors seem more influential than these specific polymorphisms in isolation. More studies are warranted to clarify the role of the TM6SF2 and PNPLA3 polymorphisms in Brazilians with HCV.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

The role of PNPLA3 and TM6SF2 polymorphisms on liver fibrosis and metabolic abnormalities in Brazilian patients with chronic hepatitis C

Oliveira, Arthur Ivan N ; Malta, Fernanda M ; Zitelli, Patricia Momoyo Y ; Salles, Ana Paula M ; Gomes-Gouvea, Michele S ; Nastri, Ana Catharina S ; Pinho, Joao Renato R ; Carrilho, Flair J ; Oliveira, Claudia P ; Mendes-Corrêa, Maria Cássia ; Pessoa, Mario G ; Mazo, Daniel F

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.