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Induction of Long-Term Potentiation and Depression Is Reflected by Corresponding Changes in Secretion of Endogenous Brain-Derived Neurotrophic Factor

Aicardi, Giorgio ; Argilli, Emanuela ; Cappello, Silvia ; Santi, Spartaco ; Riccio, Massimo ; Thoenen, Hans ; Canossa, Marco

Proceedings of the National Academy of Sciences - PNAS, 2004-11, Vol.101 (44), p.15788-15792 [Revista revisada por pares]

United States: National Academy of Sciences

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Induction of Long-Term Potentiation and Depression Is Reflected by Corresponding Changes in Secretion of Endogenous Brain-Derived Neurotrophic Factor
Autor: Aicardi, Giorgio ; Argilli, Emanuela ; Cappello, Silvia ; Santi, Spartaco ; Riccio, Massimo ; Thoenen, Hans ; Canossa, Marco
Materias: Animals ; Biological Sciences ; Brain ; Brain - physiology ; Brain-Derived Neurotrophic Factor - metabolism ; Brain-Derived Neurotrophic Factor - physiology ; Changes ; Electrophysiology ; Entorhinal cortex ; Entorhinal Cortex - physiology ; Hippocampus ; Hippocampus - physiology ; In Vitro Techniques ; Long term ; Long term depression ; Long term potentiation ; Long-Term Synaptic Depression ; Male ; Mental depression ; Neurology ; Neurons ; Neuroscience ; Perfusion ; Physiological regulation ; Rats ; Rats, Sprague-Dawley ; Receptors ; Secretion
Es parte de: Proceedings of the National Academy of Sciences - PNAS, 2004-11, Vol.101 (44), p.15788-15792
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Abbreviations: BDNF, brain-derived neurotrophic factor; FP, field potential; LFS, low-frequency stimulation; LTD, long-term depression; LTP, long-term potentiation; NeuN, neuronal nuclear antigen; PRh, perirhinal; TBS, theta-burst stimulation; TTX, tetrodotoxin.
Contributed by Hans Thoenen, September 21, 2004
G.A., E.A., and S.C. contributed equally to this work.
To whom correspondence should be addressed. E-mail: marco@biocfarm.unibo.it.
Descripción: Neurotrophins play an important role in modulating activity-dependent neuronal plasticity. In particular, threshold levels of brain-derived neurotrophic factor (BDNF) are required to induce long-term potentiation (LTP) in acute hippocampal slices. Conversely, the administration of exogenous BDNF prevents the induction of long-term depression (LTD) in the visual cortex. A long-standing missing link in the analysis of this modulatory role of BDNF was the determination of the time-course of endogenous BDNF secretion in the same organotypic preparation in which LTP and LTD are elicited. Here, we fulfilled this requirement in slices of perirhinal cortex. Classical theta-burst stimulation patterns evoking LTP lasting >180 min elicited a large increase in BDNF secretion that persisted 5-12 min beyond the stimulation period. Weaker theta-burst stimulation patterns leading only to the initial phase of LTP (≈35 min) were accompanied by a smaller increase in BDNF secretion lasting <1 min. Sequestration of BDNF by TrkB-IgG receptor bodies prevented LTP. Low-frequency stimulations leading to LTD were accompanied by reductions in BDNF secretion that never lasted beyond the duration of the stimulation.
Editor: United States: National Academy of Sciences
Idioma: Inglés

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Induction of Long-Term Potentiation and Depression Is Reflected by Corresponding Changes in Secretion of Endogenous Brain-Derived Neurotrophic Factor

Aicardi, Giorgio ; Argilli, Emanuela ; Cappello, Silvia ; Santi, Spartaco ; Riccio, Massimo ; Thoenen, Hans ; Canossa, Marco

United States: National Academy of Sciences

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