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Presynaptic Protein Synthesis in Brain Function and Disease

Castillo, Pablo E ; Jung, Hosung ; Klann, Eric ; Riccio, Antonella

The Journal of neuroscience, 2023-11, Vol.43 (45), p.7483-7488 [Revista revisada por pares]

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Título:
Presynaptic Protein Synthesis in Brain Function and Disease
Autor: Castillo, Pablo E ; Jung, Hosung ; Klann, Eric ; Riccio, Antonella
Materias: Autism ; Axons ; Axons - physiology ; Brain ; Brain - metabolism ; Functional anatomy ; Intellectual disabilities ; Localization ; Neuronal Plasticity - physiology ; Presynapse ; Presynaptic plasticity ; Presynaptic Terminals - metabolism ; Protein biosynthesis ; Protein synthesis ; Proteins ; Proteomes ; Structure-function relationships ; Symposium and Mini-Symposium ; Synaptic plasticity ; Transcriptomes ; Translation
Es parte de: The Journal of neuroscience, 2023-11, Vol.43 (45), p.7483-7488
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Local protein synthesis in mature brain axons regulates the structure and function of presynaptic boutons by adjusting the presynaptic proteome to local demands. This crucial mechanism underlies experience-dependent modifications of brain circuits, and its dysregulation may contribute to brain disorders, such as autism and intellectual disability. Here, we discuss recent advancements in the axonal transcriptome, axonal RNA localization and translation, and the role of presynaptic local translation in synaptic plasticity and memory.
Editor: United States: Society for Neuroscience
Idioma: Inglés

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