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A 10-year molecular survey of herpes simplex virus type 1 in Germany demonstrates a stable and high prevalence of genotypes A and B

Schmidt-Chanasit, Jonas ; Bialonski, Alexandra ; Heinemann, Patrick ; Ulrich, Rainer G ; Günther, Stephan ; Rabenau, Holger F ; Doerr, Hans Wilhelm

Journal of clinical virology, 2009-03, Vol.44 (3), p.235-237 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
A 10-year molecular survey of herpes simplex virus type 1 in Germany demonstrates a stable and high prevalence of genotypes A and B
Autor: Schmidt-Chanasit, Jonas ; Bialonski, Alexandra ; Heinemann, Patrick ; Ulrich, Rainer G ; Günther, Stephan ; Rabenau, Holger F ; Doerr, Hans Wilhelm
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Allergy and Immunology ; Biological and medical sciences ; Child ; Child, Preschool ; DNA, Viral - genetics ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Genotype ; Germany ; Germany - epidemiology ; Glycoprotein ; Herpes Simplex - epidemiology ; Herpes Simplex - virology ; Herpes simplex virus 1 ; Herpes simplex virus type 1 ; Herpesvirus 1, Human - classification ; Herpesvirus 1, Human - genetics ; Herpesvirus 1, Human - isolation & purification ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infant ; Infant, Newborn ; Infectious Disease ; Infectious diseases ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Epidemiology ; Polymerase Chain Reaction - methods ; Polymorphism, Restriction Fragment Length ; Prevalence ; Recombination ; Viral diseases ; Viral Envelope Proteins - genetics ; Virology ; Young Adult
É parte de: Journal of clinical virology, 2009-03, Vol.44 (3), p.235-237
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Background Recently three different herpes simplex virus type 1 (HSV-1) genotypes (A, B and C) were described on DNA sequence data of the glycoprotein E (gE), G (gG) and I (gI) genes. Objective To type the circulating HSV-1 wild-type strains in Germany and to monitor potential changes in the molecular epidemiology over the past 10 years. Study design A total of 569 clinical HSV-1 isolates from a 10-year survey in Germany were genotyped by a PCR-based restriction fragment length polymorphism analysis of gG and gI. Recombination analysis of the gE gene sequences was performed to reveal intragenic recombinants. Results Genotypes A and B strains represented 76% of all strains analyzed and showed a stable distribution within all age groups investigated, independently from the gender. Intergenic gG/gI and intragenic gE recombinants were demonstrated to be less prevalent. Interestingly, for one HIV infected patient a gG/gI genotype switch from A/A to C/A was observed within 3 years. Conclusion The first molecular survey of clinical HSV-1 isolates from Germany demonstrated a stable distribution of two different genotypes and recombinants within age groups and over a period of 10 years. Moreover, homologous recombination seems to be an important feature in the evolution of the HSV-1 genome.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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A 10-year molecular survey of herpes simplex virus type 1 in Germany demonstrates a stable and high prevalence of genotypes A and B

Schmidt-Chanasit, Jonas ; Bialonski, Alexandra ; Heinemann, Patrick ; Ulrich, Rainer G ; Günther, Stephan ; Rabenau, Holger F ; Doerr, Hans Wilhelm

Amsterdam: Elsevier B.V

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