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Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Morgan, Robert D. ; Clamp, Andrew R. ; Jayson, Gordon C.

Treatment of Cancer, 2021, Vol.1, p.295-308

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Título:
Ovarian, Fallopian Tube, and Primary Peritoneal Cancer
Autor: Morgan, Robert D. ; Clamp, Andrew R. ; Jayson, Gordon C.
É parte de: Treatment of Cancer, 2021, Vol.1, p.295-308
Descrição: The most significant risk factors for ovarian cancer are age and a family history of the disease. Epithelial ovarian carcinomas are classified into four main histological subtypes: serous, endometrioid, clear cell, and mucinous. Ninety-five percent of women with ovarian cancer experience symptoms before diagnosis. Ovarian cancer spreads via local shedding into the peritoneal cavity and local invasion of bowel and bladder. Epithelial malignancies arising from the fallopian tube, and the peritoneum in females, occur through similar etiological pathways and demonstrate similar clinical behavior; therefore, they are managed using the same treatment algorithm(s) as epithelial ovarian cancer. Factors precluding successful primary surgery include extensive upper abdominal disease, in particular that involving the porta hepatis or mesentery, and poor performance status secondary to symptoms associated with ovarian cancer and/or comorbidities. Poly(ADP-ribose) polymerase inhibitors are a standard of care maintenance treatment in relapsed, platinum-sensitive high-grade serous or endometrioid ovarian cancer.
Editor: CRC Press
Idioma: Inglês

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