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Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion

Powell, Nicole D ; Bailey, M.T ; Mays, J.W ; Stiner-Jones, L.M ; Hanke, M.L ; Padgett, D.A ; Sheridan, John F

Brain, behavior, and immunity, 2009-02, Vol.23 (2), p.225-231 [Periódico revisado por pares]

Netherlands: Elsevier Inc

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Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion
Autor: Powell, Nicole D ; Bailey, M.T ; Mays, J.W ; Stiner-Jones, L.M ; Hanke, M.L ; Padgett, D.A ; Sheridan, John F
Assuntos: Allergy and Immunology ; Analysis of Variance ; Animals ; B7-1 Antigen - metabolism ; CD11b Antigen - metabolism ; CD11c Antigen - metabolism ; Cells, Cultured ; Cytokines - metabolism ; Dendritic cell ; Dendritic Cells - immunology ; Dominance-Subordination ; Flow Cytometry ; Genes, MHC Class I - physiology ; Glucocorticoids - metabolism ; Glucocorticoids - pharmacology ; Hyaluronan Receptors - metabolism ; Innate immunity ; Interleukin-10 - metabolism ; Interleukin-6 - metabolism ; Lipopolysaccharides - toxicity ; Male ; Mice ; Mice, Inbred C57BL ; Monocytes - immunology ; Monocytes - metabolism ; Psychiatry ; Psychoneuroimmunology ; Social stress ; Spleen - cytology ; Spleen - immunology ; Stress, Psychological - immunology ; Toll-Like Receptors - metabolism ; Tumor Necrosis Factor-alpha - metabolism
É parte de: Brain, behavior, and immunity, 2009-02, Vol.23 (2), p.225-231
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Descrição: Abstract Stress hormones significantly impact dendritic cell (DC) activation and function, typically in a suppressive fashion. However, a social stressor termed social disruption (SDR) has been shown to induce an increase in inflammatory responses and a state of glucocorticoid resistance in splenic CD11b+ monocytes. These experiments were designed to determine the effects of SDR on DC activation, Toll-like receptor-induced cytokine secretion, and glucocorticoid sensitivity. Compared to cells obtained from control animals, splenic DCs from SDR mice displayed increased levels of MHC I, CD80, and CD44, indicative of an activated phenotype. In addition, DCs from SDR mice produced comparatively higher TNF-α, IL-6, and IL-10 in response to in vitro stimulation with LPS and CpG DNA. Increased amounts of TNF-α and IL-6 were also evident in SDR DC cultures stimulated with poly(I:C). Furthermore, as shown previously in CD11b+ monocytes, the CD11c+ DCs obtained from SDR mice were glucocorticoid resistant. Taken together, the data suggest that social stress, in the absence of any immune challenge, activates DCs, increases DC cytokine secretion in response to Toll-specific stimuli and renders DCs glucocorticoid resistant.
Editor: Netherlands: Elsevier Inc
Idioma: Inglês

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Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion

Powell, Nicole D ; Bailey, M.T ; Mays, J.W ; Stiner-Jones, L.M ; Hanke, M.L ; Padgett, D.A ; Sheridan, John F

Netherlands: Elsevier Inc

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