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GABAergic neurotransmission and retinal ganglion cell function

Popova, E

Journal of Comparative Physiology, 2015-03, Vol.201 (3), p.261-283 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

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Título:
GABAergic neurotransmission and retinal ganglion cell function
Autor: Popova, E
Assuntos: Animal Physiology ; Animals ; antagonists ; Biomedical and Life Sciences ; brain ; GABA Antagonists - pharmacology ; GABAergic Neurons - drug effects ; GABAergic Neurons - metabolism ; gamma-aminobutyric acid ; gamma-Aminobutyric Acid - metabolism ; ganglia ; Humans ; Life Sciences ; Light ; Light Signal Transduction ; mammals ; neurons ; Neurosciences ; neurotransmitters ; Photic Stimulation ; physiology ; receptors ; Receptors, GABA - metabolism ; retina ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - metabolism ; Review ; Synaptic Potentials ; Synaptic Transmission - drug effects ; Zoology
É parte de: Journal of Comparative Physiology, 2015-03, Vol.201 (3), p.261-283
Notas: http://dx.doi.org/10.1007/s00359-015-0981-z
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Descrição: Ganglion cells are the output retinal neurons that convey visual information to the brain. There are ~20 different types of ganglion cells, each encoding a specific aspect of the visual scene as spatial and temporal contrast, orientation, direction of movement, presence of looming stimuli; etc. Ganglion cell functioning depends on the intrinsic properties of ganglion cell’s membrane as well as on the excitatory and inhibitory inputs that these cells receive from other retinal neurons. GABA is one of the most abundant inhibitory neurotransmitters in the retina. How it modulates the activity of different types of ganglion cells and what is its significance in extracting the basic features from visual scene are questions with fundamental importance in visual neuroscience. The present review summarizes current data concerning the types of membrane receptors that mediate GABA action in proximal retina; the effects of GABA and its antagonists on the ganglion cell light-evoked postsynaptic potentials and spike discharges; the action of GABAergic agents on centre-surround organization of the receptive fields and feature related ganglion cell activity. Special emphasis is put on the GABA action regarding the ON–OFF and sustained–transient ganglion cell dichotomy in both nonmammalian and mammalian retina.
Editor: Berlin/Heidelberg: Springer-Verlag
Idioma: Inglês

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GABAergic neurotransmission and retinal ganglion cell function

Popova, E

Berlin/Heidelberg: Springer-Verlag

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