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Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System

Knapik-Kowalczuk, Justyna ; Chmiel, Krzysztof ; Jurkiewicz, Karolina ; Correia, Natália T ; Sawicki, Wiesław ; Paluch, Marian

Pharmaceuticals (Basel, Switzerland), 2019-03, Vol.12 (1), p.40 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System
Autor: Knapik-Kowalczuk, Justyna ; Chmiel, Krzysztof ; Jurkiewicz, Karolina ; Correia, Natália T ; Sawicki, Wiesław ; Paluch, Marian
Assuntos: Bioavailability ; Cholesterol ; co-amorphous ; Condensed Matter ; Crystallization ; Drug dosages ; ezetimibe ; Life Sciences ; Materials Science ; Medication ; melt viscosity ; Pharmaceutical sciences ; Pharmaceuticals ; Physics ; simvastatin ; Soft Condensed Matter ; solubility enhancement ; Viscoelasticity ; Viscosity
É parte de: Pharmaceuticals (Basel, Switzerland), 2019-03, Vol.12 (1), p.40
Descrição: The purpose of this paper is to examine the physical stability as well as viscoelastic properties of the binary amorphous ezetimibe⁻simvastatin system. According to our knowledge, this is the first time that such an amorphous composition is prepared and investigated. The tendency toward re-crystallization of the amorphous ezetimibe⁻simvastatin system, at both standard storage and elevated temperature conditions, have been studied by means of X-ray diffraction (XRD). Our investigations have revealed that simvastatin remarkably improves the physical stability of ezetimibe, despite the fact that it works as a plasticizer. Pure amorphous ezetimibe, when stored at room temperature, begins to re-crystallize after 14 days after amorphization. On the other hand, the ezetimibe-simvastatin binary mixture (at the same storage conditions) is physically stable for at least 1 year. However, the devitrification of the binary amorphous composition was observed at elevated temperature conditions ( = 373 K). Therefore, we used a third compound to hinder the re-crystallization. Finally, both the physical stability as well as viscoelastic properties of the ternary systems containing different concentrations of the latter component have been thoroughly investigated.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Physical Stability and Viscoelastic Properties of Co-Amorphous Ezetimibe/Simvastatin System

Knapik-Kowalczuk, Justyna ; Chmiel, Krzysztof ; Jurkiewicz, Karolina ; Correia, Natália T ; Sawicki, Wiesław ; Paluch, Marian

Switzerland: MDPI AG

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