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Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats

Campos, V.F ; Miranda-Ferreira, R ; Taha, N.S.A ; Teixeira, G.D ; Souza, W.T.I ; Carmo, C.E.F ; Silva-Neto, L.A ; Gomes, I.T ; Monteiro, H.P ; Montero, E.F.S ; Fagundes, D.J ; Caricati-Neto, A ; Taha, M.O

Transplantation proceedings, 2012-10, Vol.44 (8), p.2313-2316 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

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Título:
Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats
Autor: Campos, V.F ; Miranda-Ferreira, R ; Taha, N.S.A ; Teixeira, G.D ; Souza, W.T.I ; Carmo, C.E.F ; Silva-Neto, L.A ; Gomes, I.T ; Monteiro, H.P ; Montero, E.F.S ; Fagundes, D.J ; Caricati-Neto, A ; Taha, M.O
Assuntos: Adrenergic beta-1 Receptor Antagonists - pharmacology ; Animals ; Atenolol - pharmacology ; Biological and medical sciences ; Cytoprotection ; Disease Models, Animal ; Electric Stimulation ; Enteric Nervous System - drug effects ; Enteric Nervous System - physiopathology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastrointestinal Agents - pharmacology ; Gastrointestinal Motility - drug effects ; Jejunum - blood supply ; Jejunum - drug effects ; Jejunum - innervation ; Jejunum - pathology ; Jejunum - physiopathology ; Male ; Medical sciences ; Other diseases. Semiology ; Potassium Chloride - pharmacology ; Rats ; Rats, Wistar ; Reperfusion Injury - pathology ; Reperfusion Injury - physiopathology ; Reperfusion Injury - prevention & control ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology
É parte de: Transplantation proceedings, 2012-10, Vol.44 (8), p.2313-2316
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Abstract To study whether treatment with the beta-blocker atenolol (AT) attenuates intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were treated with AT (1.5 mg · kg−1 , intravenously) or saline solution (SS) prior to I (60 minutes), which was produced by occlusion of the superior mesenteric artery, and/or R (120 minutes). After I or I/R, 2-cm jejunal segments were mounted in an organ bath to study neurogenic contractions stimulated by electrical pulses or KCl using a digital recording system. Thin jejunal slices were stained with hematoxylin and eosin for optical microscopy analysis. Compared to the sham group, jejunal contractions were similar in the I + AT and the I/R + AT groups, but reduced in the I + SS and the I/R + SS groups. The jejunal enteric nerves were damaged in the I + SS and the I/R + SS groups, but not in the I + AT and the I/R + AT. These results suggest that AT may attenuate intestinal dysfunction caused by I and I/R.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

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Atenolol to Treat Intestinal Ischemia and Reperfusion in Rats

Campos, V.F ; Miranda-Ferreira, R ; Taha, N.S.A ; Teixeira, G.D ; Souza, W.T.I ; Carmo, C.E.F ; Silva-Neto, L.A ; Gomes, I.T ; Monteiro, H.P ; Montero, E.F.S ; Fagundes, D.J ; Caricati-Neto, A ; Taha, M.O

Amsterdam: Elsevier Inc

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