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Multi-step continuous-flow synthesis

Britton, Joshua ; Raston, Colin L

Chemical Society reviews, 2017-03, Vol.46 (5), p.125-1271 [Periódico revisado por pares]

England

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  • Título:
    Multi-step continuous-flow synthesis
  • Autor: Britton, Joshua ; Raston, Colin L
  • Assuntos: Biocompatibility ; Evolution ; Flasks ; Organic chemistry ; Progressions ; Scaling up ; Synthesis ; Transformations
  • É parte de: Chemical Society reviews, 2017-03, Vol.46 (5), p.125-1271
  • Notas: Prof. Colin Raston AO is SA Premier's Professorial Research Fellow in Clean Technology. He completed a PhD with Prof Allan White, and after postdoctoral studies with Prof. Michael Lappert at the University of Sussex, was appointed a lecturer at The University of Western Australia then to chairs at Griffith, Monash, Leeds (2001) and UWA (2003), before moving to Flinders University in 2013. Awards from the RACI include the Leighton Memorial Award and his former Presidency. He is an Officer of the Order of Australia and his research interests include nano- and green chemistry as well as microfluidics.
    Dr Joshua Britton earned his MSci at the University of Nottingham, UK and undertook his PhD studies at The University of California, Irvine and Flinders University, South Australia under the guidance of Prof. Gregory A. Weiss and Prof. Colin L. Raston. He is currently a postdoctoral associate with Prof. Timothy F. Jamison at MIT. His research interests include merging the power of biocatalysis with multi-step organic synthesis in continuous-flow systems for on demand compound generation. His awards include the Kipping (2011), GSK (2011), Syngenta (2012) British Petroleum Award (2013), and Taihi Hong Memorial award (2015).
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  • Descrição: Organic chemistry is continually evolving to improve the syntheses of value added and bioactive compounds. Through this progression, a concomitant advancement in laboratory technology has occurred. Many researchers now choose to mediate transformations in continuous-flow systems given the many benefits over round bottom flasks. Furthermore, reaction scale up is often less problematic as this is addressed at the inception of the science. Although single-step transformations in continuous-flow systems are common, multi-step transformations are more valuable. In these systems, molecular complexity is accrued through sequential transformations to a mobile scaffold, much like an in vitro version of Nature's polyketide synthases. Utilizing this methodology, multi-step continuous-flow systems have improved the syntheses of active pharmaceutical ingredients (APIs), natural products, and commodity chemicals. This Review details these advancements while highlighting the rapid progress, benefits, and diversification of this expanding field. Multi-step organic synthesis in continuous-flow systems has been Reviewed from 2009 onwards.
  • Editor: England
  • Idioma: Inglês
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