Idioma:

Clinical features of allogeneic hematopoietic stem cell transplantation-associated organizing pneumonia

JINTA, M ; OHASHI, K ; OHTA, T ; IEKI, R ; ABE, K ; KAMATA, N ; AKIYAMA, H ; SAKAMAKI, H

Bone marrow transplantation (Basingstoke), 2007-09, Vol.40 (5), p.465-472 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Clinical features of allogeneic hematopoietic stem cell transplantation-associated organizing pneumonia
Autor: JINTA, M ; OHASHI, K ; OHTA, T ; IEKI, R ; ABE, K ; KAMATA, N ; AKIYAMA, H ; SAKAMAKI, H
Assuntos: Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibiotics ; Bacterial pneumonia ; Biological and medical sciences ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Chronic infection ; Complications and side effects ; Cough ; Cytomegalovirus ; Cytomegalovirus Infections ; Diagnosis ; Dyspnea ; Female ; Fever ; Graft versus host disease ; Graft versus host reaction ; Graft vs Host Disease ; Health services ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic stem cells ; Humans ; Irradiation ; Male ; Medical sciences ; Medical treatment ; Middle Aged ; Patients ; Pneumonia ; Pneumonia - drug therapy ; Pneumonia - etiology ; Pneumonia - mortality ; Prednisolone ; Prednisolone - therapeutic use ; Prevention ; Radiation ; Radiotherapy ; Respiration ; Retrospective Studies ; Risk Factors ; Signs and symptoms ; Stem cell transplantation ; Stem cells ; Survival ; Survival Rate ; Tapering ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Conditioning - methods ; Transplantation, Homologous
É parte de: Bone marrow transplantation (Basingstoke), 2007-09, Vol.40 (5), p.465-472
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: We describe the clinical courses and outcomes of allogeneic hematopoietic stem cell transplantation-associated organizing pneumonia (HOP) observed in our institution over the past 20 years. Charts and chest radiographs of 603 allogeneic transplant recipients were retrospectively reviewed for HOP. In total, 12 cases of HOP were identified (2.0%) at a median interval of 148 days after transplantation (range, 53-475 days), presenting with low-grade fever, nonproductive cough and dyspnea at onset. Initial antibiotic treatment did not ameliorate symptoms, but most patients responded well to 0.5-1 mg/kg of prednisolone. HOP flare-up occurred after discontinuing treatment or while tapering doses in 9 of 12 patients, but responded to re-treatment with the initial dose of steroid. Although three patients died, no deaths were attributable to pulmonary failure. The remaining nine patients displayed no relapse of primary disease and 5-year survival rate was 74.1%. Clinical features of the 12 patients were similar in that all underwent irradiation-containing conditioning and most had a prior history of acute graft-versus-host disease (GVHD) and cytomegalovirus (CMV) infection. Furthermore, eight patients had active chronic GVHD at onset of HOP. These findings suggest that factors such as irradiation-containing regimens, previous CMV infection and allogeneic immune reaction may contribute to HOP occurrence.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 5 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Clinical features of allogeneic hematopoietic stem cell transplantation-associated organizing pneumonia

JINTA, M ; OHASHI, K ; OHTA, T ; IEKI, R ; ABE, K ; KAMATA, N ; AKIYAMA, H ; SAKAMAKI, H

Basingstoke: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.