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Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes: A nationwide population-based study

HSU, Pai-Feng ; SUNG, Shih-Hsien ; CHENG, Hao-Min ; YEH, Jong-Shiuan ; LIU, Wen-Ling ; CHAN, Wan-Leong ; CHEN, Chen-Huan ; CHOU, Pesus ; CHUANG, Srao-Yuan

Diabetes care, 2013-04, Vol.36 (4), p.894-900 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes: A nationwide population-based study
Autor: HSU, Pai-Feng ; SUNG, Shih-Hsien ; CHENG, Hao-Min ; YEH, Jong-Shiuan ; LIU, Wen-Ling ; CHAN, Wan-Leong ; CHEN, Chen-Huan ; CHOU, Pesus ; CHUANG, Srao-Yuan
Assuntos: Aged ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Complications and side effects ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - mortality ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Health insurance ; Heart attacks ; Hospitalization ; Hospitals ; Humans ; Hypoglycemia ; Hypoglycemia - blood ; Hypoglycemia - complications ; Hypoglycemia - mortality ; Male ; Medical research ; Medical sciences ; Metabolic diseases ; Middle Aged ; Miscellaneous ; Original Research ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Studies ; Type 2 diabetes
É parte de: Diabetes care, 2013-04, Vol.36 (4), p.894-900
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Hypoglycemia is associated with serious health outcomes for patients treated for diabetes. However, the outcome of outpatients with type 2 diabetes who have experienced hypoglycemia episodes is largely unknown. The study population, derived from the National Health Insurance Research Database released by the Taiwan National Health Research Institutes during 1998-2009, comprised 77,611 patients with newly diagnosed type 2 diabetes. We designed a prospective study consisting of randomly selected hypoglycemic type 2 diabetic patients and matched type 2 diabetic patients without hypoglycemia. We investigated the relationships of hypoglycemia with total mortality and cardiovascular events, including stroke, coronary heart disease, cardiovascular diseases, and all-cause hospitalization. There were 1,844 hypoglycemic events (500 inpatients and 1,344 outpatients) among the 77,611 patients. Both mild (outpatient) and severe (inpatient) hypoglycemia cases had a higher percentage of comorbidities, including hypertension, renal diseases, cancer, stroke, and heart disease. In multivariate Cox regression models, including diabetes treatment adjustment, diabetic patients with hypoglycemia had a significantly higher risk of cardiovascular events during clinical treatment periods. After constructing a model adjusted with propensity scores, mild and severe hypoglycemia still demonstrated higher hazard ratios (HRs) for cardiovascular diseases (HR 2.09 [95% CI 1.63-2.67]), all-cause hospitalization (2.51 [2.00-3.16]), and total mortality (2.48 [1.41-4.38]). Symptomatic hypoglycemia, whether clinically mild or severe, is associated with an increased risk of cardiovascular events, all-cause hospitalization, and all-cause mortality. More attention may be needed for diabetic patients with hypoglycemic episodes.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes: A nationwide population-based study

HSU, Pai-Feng ; SUNG, Shih-Hsien ; CHENG, Hao-Min ; YEH, Jong-Shiuan ; LIU, Wen-Ling ; CHAN, Wan-Leong ; CHEN, Chen-Huan ; CHOU, Pesus ; CHUANG, Srao-Yuan

Alexandria, VA: American Diabetes Association

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