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The cerebrospinal fluid “Alzheimer profile”: Easily said, but what does it mean?

Duits, Flora H ; Teunissen, Charlotte E ; Bouwman, Femke H ; Visser, Pieter-Jelle ; Mattsson, Niklas ; Zetterberg, Henrik ; Blennow, Kaj ; Hansson, Oskar ; Minthon, Lennart ; Andreasen, Niels ; Marcusson, Jan ; Wallin, Anders ; Rikkert, Marcel Olde ; Tsolaki, Magda ; Parnetti, Lucilla ; Herukka, Sanna-Kaisa ; Hampel, Harald ; De Leon, Mony J ; Schröder, Johannes ; Aarsland, Dag ; Blankenstein, Marinus A ; Scheltens, Philip ; van der Flier, Wiesje M

Alzheimer's & dementia, 2014-11, Vol.10 (6), p.713-723.e2 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The cerebrospinal fluid “Alzheimer profile”: Easily said, but what does it mean?
Autor: Duits, Flora H ; Teunissen, Charlotte E ; Bouwman, Femke H ; Visser, Pieter-Jelle ; Mattsson, Niklas ; Zetterberg, Henrik ; Blennow, Kaj ; Hansson, Oskar ; Minthon, Lennart ; Andreasen, Niels ; Marcusson, Jan ; Wallin, Anders ; Rikkert, Marcel Olde ; Tsolaki, Magda ; Parnetti, Lucilla ; Herukka, Sanna-Kaisa ; Hampel, Harald ; De Leon, Mony J ; Schröder, Johannes ; Aarsland, Dag ; Blankenstein, Marinus A ; Scheltens, Philip ; van der Flier, Wiesje M
Assuntos: Aged ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - complications ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Amyloid beta-Peptides - cerebrospinal fluid ; Amyloid-β1-42 ; Analysis of Variance ; Apolipoproteins E - genetics ; Biomarkers ; Cerebrospinal fluid ; Clinical Medicine ; Cognition Disorders - etiology ; Cohort Studies ; Dementia ; Diagnosis, Differential ; Differential diagnosis ; Female ; Humans ; Kaplan-Meier Estimate ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Mild cognitive impairment ; Netherlands ; Neurologi ; Neurology ; Neurosciences ; Neurovetenskaper ; Peptide Fragments - cerebrospinal fluid ; Phosphorylation ; Predictive value ; Regression Analysis ; ROC Curve ; Tau ; tau Proteins - cerebrospinal fluid
É parte de: Alzheimer's & dementia, 2014-11, Vol.10 (6), p.713-723.e2
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Background We aimed to identify the most useful definition of the “cerebrospinal fluid Alzheimer profile,” based on amyloid-ß1-42 (Aβ42 ), total tau, and phosphorylated tau (p-tau), for diagnosis and prognosis of Alzheimer's disease (AD). Methods We constructed eight Alzheimer profiles with previously published combinations, including regression formulas and simple ratios. We compared their diagnostic accuracy and ability to predict dementia due to AD in 1385 patients from the Amsterdam Dementia Cohort. Results were validated in an independent cohort (n = 1442). Results Combinations outperformed individual biomarkers. Based on the sensitivity of the best performing regression formulas, cutoffs were chosen at 0.52 for the tau/Aβ42 ratio and 0.08 for the p-tau/Aβ42 ratio. Ratios performed similar to formulas (sensitivity, 91%–93%; specificity, 81%–84%). The same combinations best predicted cognitive decline in mild cognitive impairment patients. Validation confirmed these results, especially regarding the tau/Aβ42 ratio. Conclusions A tau/Aβ42 ratio of >0.52 constitutes a robust cerebrospinal fluid Alzheimer profile. We recommend using this ratio to combine biomarkers.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The cerebrospinal fluid “Alzheimer profile”: Easily said, but what does it mean?

United States: Elsevier Inc

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