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Apolipoprotein E genotypes and longevity across dementia disorders

Skillbäck, Tobias ; Lautner, Ronald ; Mattsson, Niklas ; Schott, Jonathan M. ; Skoog, Ingmar ; Nägga, Katarina ; Kilander, Lena ; Wimo, Anders ; Winblad, Bengt ; Eriksdotter, Maria ; Blennow, Kaj ; Zetterberg, Henrik

Alzheimer's & dementia, 2018-07, Vol.14 (7), p.895-901 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Apolipoprotein E genotypes and longevity across dementia disorders
Autor: Skillbäck, Tobias ; Lautner, Ronald ; Mattsson, Niklas ; Schott, Jonathan M. ; Skoog, Ingmar ; Nägga, Katarina ; Kilander, Lena ; Wimo, Anders ; Winblad, Bengt ; Eriksdotter, Maria ; Blennow, Kaj ; Zetterberg, Henrik
Assuntos: Alzheimer's disease ; Apolipoprotein E ; Clinical Medicine ; Creutzfeldt-Jakob disease ; Dementia with Lewy bodies ; Frontotemporal dementia ; Klinisk medicin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Neurologi ; Neurology ; Neurosciences ; Neurovetenskaper ; Parkinson's disease dementia ; Vascular dementia
É parte de: Alzheimer's & dementia, 2018-07, Vol.14 (7), p.895-901
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SourceType-Scholarly Journals-1
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Descrição: The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied. We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity. The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders. The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common. •The ɛ4 allele is associated with reduced longevity and a more distinct Alzheimer's disease (AD)-like biomarker profile in dementia in general, and in AD in particular.•The ɛ4 allele is prominent in AD, but also in vascular dementia and in mixed vascular dementia and AD.•The ɛ4 allele is associated with an earlier disease onset in AD.•The effects of APOE genotype in frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease dementia, and Creutzfeldt-Jakob disease are small.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Apolipoprotein E genotypes and longevity across dementia disorders

Skillbäck, Tobias ; Lautner, Ronald ; Mattsson, Niklas ; Schott, Jonathan M. ; Skoog, Ingmar ; Nägga, Katarina ; Kilander, Lena ; Wimo, Anders ; Winblad, Bengt ; Eriksdotter, Maria ; Blennow, Kaj ; Zetterberg, Henrik

United States: Elsevier Inc

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