Vav and Rac Activation in B Cell Antigen Receptor Endocytosis Involves Vav Recruitment to the Adapter Protein LAB

• Autor: Malhotra, Shikha ; Kovats, Susan ; Zhang, Weiguo ; Coggeshall, K.Mark
• Assuntos: Adaptor Proteins, Vesicular Transport - genetics ; Adaptor Proteins, Vesicular Transport - immunology ; Adaptor Proteins, Vesicular Transport - metabolism ; Animals ; Antigen Presentation - physiology ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; Cell Line, Tumor ; Dynamins - genetics ; Dynamins - immunology ; Dynamins - metabolism ; Endocytosis - physiology ; GRB2 Adaptor Protein - genetics ; GRB2 Adaptor Protein - immunology ; GRB2 Adaptor Protein - metabolism ; Mechanisms of Signal Transduction ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Neuropeptides - genetics ; Neuropeptides - immunology ; Neuropeptides - metabolism ; Phosphorylation - physiology ; Proto-Oncogene Proteins c-vav - genetics ; Proto-Oncogene Proteins c-vav - immunology ; Proto-Oncogene Proteins c-vav - metabolism ; rac GTP-Binding Proteins - genetics ; rac GTP-Binding Proteins - immunology ; rac GTP-Binding Proteins - metabolism ; rac1 GTP-Binding Protein ; RAC2 GTP-Binding Protein ; Receptors, Antigen, B-Cell - genetics ; Receptors, Antigen, B-Cell - immunology ; Receptors, Antigen, B-Cell - metabolism ; Signal Transduction - physiology ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism
• É parte de: The Journal of biological chemistry, 2009-12, Vol.284 (52), p.36202-36212
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• Descrição: The signal transduction events supporting B cell antigen receptor (BCR) endocytosis are not well understood. We have identified a pathway supporting BCR internalization that begins with tyrosine phosphorylation of the adapter protein LAB. Phosphorylated LAB recruits a complex of Grb2-dynamin and the guanine nucleotide exchange factor Vav. Vav is required for activation of the small GTPases Rac1 and Rac2. All these proteins contribute to (and dynamin, Vav, and Rac1/2 are required for) BCR endocytosis and presentation of antigen to T cells. This is the first description of a sequential signal transduction pathway from BCR to internalization and antigen presentation.
  
• Editor: United States: Elsevier Inc
  
• Idioma: Inglês