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Comparative genomic analysis of three Leishmania species that cause diverse human disease

Ivens, Alasdair ; Peacock, Christopher S ; Carver, Tim ; Thurston, Scott ; Tivey, Adrian ; Chillingworth, Tracey ; Baldauf, Sandra L ; Smith, Deborah F ; Oyola, Samuel O ; Faulconbridge, Adam ; Barrell, Barclay ; Brito, Loislene O ; Jeffares, Daniel ; Arrowsmith, Claire ; Jagels, Kay ; Norbertczak, Halina ; Squares, Rob ; Whitehead, Sally ; Rajandream, Marie-Adele ; Cruz, Angela K ; Tosi, Luiz R O ; Ormond, Doug ; Hance, Zahra ; Seeger, Kathy ; Peters, Nick ; Mottram, Jeremy C ; White, Brian ; Moule, Sharon ; Murphy, Lee ; Depledge, Daniel P ; Harris, David ; Berriman, Matthew ; Hilley, James D ; Fraser, Audrey ; Rabbinowitsch, Ester ; Bringaud, Frédéric ; Ruiz, Jeronimo C ; Quail, Michael A ; Kerhornou, Arnaud ; Rutter, Simon ; Aslett, Martin ; Adlem, Ellen

Nature genetics, 2007-07, Vol.39 (7), p.839-847 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Comparative genomic analysis of three Leishmania species that cause diverse human disease
Autor: Ivens, Alasdair ; Peacock, Christopher S ; Carver, Tim ; Thurston, Scott ; Tivey, Adrian ; Chillingworth, Tracey ; Baldauf, Sandra L ; Smith, Deborah F ; Oyola, Samuel O ; Faulconbridge, Adam ; Barrell, Barclay ; Brito, Loislene O ; Jeffares, Daniel ; Arrowsmith, Claire ; Jagels, Kay ; Norbertczak, Halina ; Squares, Rob ; Whitehead, Sally ; Rajandream, Marie-Adele ; Cruz, Angela K ; Tosi, Luiz R O ; Ormond, Doug ; Hance, Zahra ; Seeger, Kathy ; Peters, Nick ; Mottram, Jeremy C ; White, Brian ; Moule, Sharon ; Murphy, Lee ; Depledge, Daniel P ; Harris, David ; Berriman, Matthew ; Hilley, James D ; Fraser, Audrey ; Rabbinowitsch, Ester ; Bringaud, Frédéric ; Ruiz, Jeronimo C ; Quail, Michael A ; Kerhornou, Arnaud ; Rutter, Simon ; Aslett, Martin ; Adlem, Ellen
Assuntos: Amino Acid Sequence ; Animals ; Biologi ; Biological and medical sciences ; Biology ; Biomedical research ; Diagnosis ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genetic aspects ; Genetics of eukaryotes. Biological and molecular evolution ; Genome ; Genomics ; Health aspects ; Humans ; Leishmania - genetics ; Leishmania braziliensis ; Leishmania braziliensis - genetics ; Leishmania infantum ; Leishmania infantum - genetics ; Leishmania major ; Leishmania major - genetics ; Leishmaniasis ; Leishmaniasis - parasitology ; Leishmaniasis, Cutaneous - parasitology ; Leishmaniasis, Visceral - parasitology ; Life Sciences ; Microbiology and Parasitology ; Molecular Sequence Data ; NATURAL SCIENCES ; NATURVETENSKAP ; Parasites ; Parasitology ; Physiological aspects ; Proteins ; Ribonucleic acid ; Risk factors ; RNA
É parte de: Nature genetics, 2007-07, Vol.39 (7), p.839-847
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PMCID: PMC2592530
AUTHOR CONTRIBUTIONS C.S.P., M.B., D.F.S., A.K.C., J.C.M. and B.B. worked on all aspects of work, contributed to the design of the project and wrote the article. C.S.P. and J.C.R. annotated the genomes; K.S., D.H. and L.M. carried out the assembly and finishing of the genomes; A.F., T.C., Z.H., K.J., S.M., D.O., S.R., R.S., S.W., C.A. and B.W. sequenced the genomes and M.A.Q., H.N., E.R. and S.T. made the clone libraries. N.P., E.A., A.T., M.A., A.K., A.I., M.-A.R. and T.C. wrote and developed software for annotation and comparative analysis of the three genome sequences. F.B. worked on identifying the transposable elements, and S.L.B. and A.F. worked on the phylogenetic analysis of CFA synthase. A.K.C., L.O.B. and L.R.O.T. elucidated the RNAi pathway. D.J. performed the evolutionary analysis, and D.P.D. analyzed the amino acid repeats. D.F.S., J.C.M., S.O.O. and J.D.H. worked on some of the species-specific genes.
Descrição: Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Comparative genomic analysis of three Leishmania species that cause diverse human disease

London: Nature Publishing Group

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