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The plasticity of plasticity: lesson from remote microglia induced by focal central nervous system injury

Viscomi, Maria

Neural regeneration research, 2020-01, Vol.15 (1), p.57-58 [Periódico revisado por pares]

India: Wolters Kluwer India Pvt. Ltd

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  • Título:
    The plasticity of plasticity: lesson from remote microglia induced by focal central nervous system injury
  • Autor: Viscomi, Maria
  • Assuntos: Care and treatment ; Central nervous system ; Health aspects ; Inflammation ; Injuries ; Medical imaging ; Microglia ; Morphology ; Nervous system ; Neurons ; Neurophysiology ; Neuroplasticity ; Sports injuries ; Traumatic brain injury
  • É parte de: Neural regeneration research, 2020-01, Vol.15 (1), p.57-58
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The study of the cellular, molecular, functional and structural mechanisms involved in brain plasticity has clearly emphasized the multitude of players engaged in this phenomenon, leading to the conceptualization that non-neuronal cells and non-neuronal mechanisms intervene in these changes and orchestrate some of the responses observed (Werner and Stevens, 2015). Multiple signals converge on microglia and contribute to their dynamism, which includes morphological changes, altered expression of cell surface markers and inflammation-related genes, increased phagocytic capacity, and greater proliferation and migration at the site of damage (Kettenmann et al., 2011). After brain or spinal cord focal injury remote damage might result from an axonal lesion or from trans-neuronal effects leading to spread of damage signals along anatomical and functional connections, and it can be either anterograde or retrograde, indicating the direction of the degeneration relative to the prime site of injury (Viscomi and Molinari, 2014). Since the occurrence of such secondary responses beyond the primary lesion site can interfere with the integrity and function of several neuronal networks, remote damage is particularly relevant because it may act as a decisional node in functional recovery (Zhang et al., 2012). [...]it is undeniable that the microglia responses to injury are complex and multifaceted and that its dynamism can be considered a distinctive epiphenomenon of the altered cell-to-cell communication induced by damage.
  • Editor: India: Wolters Kluwer India Pvt. Ltd
  • Idioma: Inglês;Chinês
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