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The Nucleotide Sequences of the Untranslated 5′Regions of Human α - and β -Globin mRNAs

Chang, Judy C. ; Temple, Gary F. ; Poon, Raymond ; Neumann, Kurt H. ; Kan, Yuet Wai

Proceedings of the National Academy of Sciences - PNAS, 1977-11, Vol.74 (11), p.5145-5149 [Periódico revisado por pares]

United States: National Academy of Sciences of the United States of America

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Título:
The Nucleotide Sequences of the Untranslated 5′Regions of Human α - and β -Globin mRNAs
Autor: Chang, Judy C. ; Temple, Gary F. ; Poon, Raymond ; Neumann, Kurt H. ; Kan, Yuet Wai
Assuntos: Base Sequence ; Complementary DNA ; DNA ; DNA Restriction Enzymes ; Five prime untranslated regions ; Gels ; Globins - biosynthesis ; Humans ; Messenger RNA ; Nucleotide sequences ; Nucleotides ; Protein Biosynthesis ; RNA, Messenger ; Sequencing ; Three prime untranslated regions ; Untranslated regions
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1977-11, Vol.74 (11), p.5145-5149
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The complete sequences of the untranslated 5′regions of human α - and β -globin mRNAs were determined by sequence analysis of full-length cDNAs. The single-stranded cDNAs were digested with the restriction endonuclease Hae III, and the two 3′-terminal fragments of 75 and 132 nucleotides, complementary to the 5′termini of the α - and β -globin mRNAs, respectively, were isolated and sequenced. Including the initiation codon AUG, the untranslated 5′regions of human α - and β -globin mRNAs contain 41 and 54 nucleotides, respectively, and exhibit striking homologies with the corresponding sequences in the rabbit. Human α - and β -globin mRNAs have five bases in the region of the initiation codon that may form base pairs with the 3′terminus of 18S rRNA. Stable secondary structures with hairpin loops can be constructed in the untranslated 5′regions.
Editor: United States: National Academy of Sciences of the United States of America
Idioma: Inglês

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The Nucleotide Sequences of the Untranslated 5′Regions of Human α - and β -Globin mRNAs

Chang, Judy C. ; Temple, Gary F. ; Poon, Raymond ; Neumann, Kurt H. ; Kan, Yuet Wai

United States: National Academy of Sciences of the United States of America

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