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Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids

Sturm, Angelika ; Amino, Rogerio ; Sand, Claudia van de ; Regen, Tommy ; Retzlaff, Silke ; Rennenberg, Annika ; Krueger, Andreas ; Pollok, Jörg-Matthias ; Menard, Robert ; Heussler, Volker T

Science (American Association for the Advancement of Science), 2006-09, Vol.313 (5791), p.1287-1290 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids
Autor: Sturm, Angelika ; Amino, Rogerio ; Sand, Claudia van de ; Regen, Tommy ; Retzlaff, Silke ; Rennenberg, Annika ; Krueger, Andreas ; Pollok, Jörg-Matthias ; Menard, Robert ; Heussler, Volker T
Assuntos: Animals ; Biological and medical sciences ; Blood Vessels - parasitology ; Budding ; Calcium - metabolism ; Cell Adhesion ; Cell Death ; Cell Line, Tumor ; Cell Membrane - metabolism ; Cell membranes ; Cellular biology ; Cellular Structures - parasitology ; Cellular Structures - ultrastructure ; Endothelial Cells - parasitology ; Erythrocytes - parasitology ; Hep G2 cells ; Hepatocytes ; Hepatocytes - parasitology ; Hepatocytes - physiology ; Hepatocytes - ultrastructure ; Human protozoal diseases ; Humans ; Immune system ; Infectious diseases ; Ionomycin - pharmacology ; Kupffer cells ; Life Sciences ; Liver ; Liver - blood supply ; Liver - parasitology ; Malaria ; Malaria - parasitology ; Medical sciences ; Merozoites ; Mice ; Mice, Inbred C57BL ; Microbiology and Parasitology ; Parasite hosts ; Parasites ; Parasitic diseases ; Phagocytes ; Phagocytosis ; Phosphatidylserines - metabolism ; Plasmodium berghei ; Plasmodium berghei - growth & development ; Plasmodium berghei - pathogenicity ; Protozoal diseases ; Sporozoites - growth & development ; Vacuoles - parasitology ; Vacuoles - ultrastructure
É parte de: Science (American Association for the Advancement of Science), 2006-09, Vol.313 (5791), p.1287-1290
Notas: http://www.scienceonline.org/
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Descrição: The merozoite stage of the malaria parasite that infects erythrocytes and causes the symptoms of the disease is initially formed inside host hepatocytes. However, the mechanism by which hepatic merozoites reach blood vessels (sinusoids) in the liver and escape the host immune system before invading erythrocytes remains unknown. Here, we show that parasites induce the death and the detachment of their host hepatocytes, followed by the budding of parasite-filled vesicles (merosomes) into the sinusoid lumen. Parasites simultaneously inhibit the exposure of phosphatidylserine on the outer leaflet of host plasma membranes, which act as "eat me" signals to phagocytes. Thus, the hepatocyte-derived merosomes appear to ensure both the migration of parasites into the bloodstream and their protection from host immunity.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Manipulation of Host Hepatocytes by the Malaria Parasite for Delivery into Liver Sinusoids

Sturm, Angelika ; Amino, Rogerio ; Sand, Claudia van de ; Regen, Tommy ; Retzlaff, Silke ; Rennenberg, Annika ; Krueger, Andreas ; Pollok, Jörg-Matthias ; Menard, Robert ; Heussler, Volker T

Washington, DC: American Association for the Advancement of Science

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