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Role of host cell traversal by the malaria sporozoite during liver infection

Tavares, Joana ; Formaglio, Pauline ; Thiberge, Sabine ; Mordelet, Elodie ; Van Rooijen, Nico ; Medvinsky, Alexander ; Ménard, Robert ; Amino, Rogerio

The Journal of experimental medicine, 2013-05, Vol.210 (5), p.905-915 [Periódico revisado por pares]

United States: Rockefeller University Press

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Role of host cell traversal by the malaria sporozoite during liver infection
Autor: Tavares, Joana ; Formaglio, Pauline ; Thiberge, Sabine ; Mordelet, Elodie ; Van Rooijen, Nico ; Medvinsky, Alexander ; Ménard, Robert ; Amino, Rogerio
Assuntos: Animals ; Anopheles - parasitology ; Cell Death ; Cell Movement ; Endothelial Cells - parasitology ; Endothelial Cells - pathology ; Female ; Green Fluorescent Proteins - metabolism ; Host-Parasite Interactions - immunology ; Kupffer Cells - parasitology ; Kupffer Cells - pathology ; Life Sciences ; Liver - parasitology ; Liver - pathology ; Malaria - parasitology ; Malaria - pathology ; Male ; Mice ; Mice, Inbred C57BL ; Microbiology and Parasitology ; Plasmodium berghei - cytology ; Plasmodium berghei - physiology ; Sporozoites - cytology ; Sporozoites - physiology
É parte de: The Journal of experimental medicine, 2013-05, Vol.210 (5), p.905-915
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC3646492
Elodie Mordelet’s present address is INSERM U1049, Université de Bordeaux 2, 33076 Bordeaux, France.
Descrição: Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a hepatocyte and multiplying into erythrocyte-infecting forms, but how sporozoites reach hepatocytes in the liver and the role of host cell traversal (CT) remain unclear. We report the first quantitative imaging study of sporozoite liver infection in rodents. We show that sporozoites can cross the liver sinusoidal barrier by multiple mechanisms, targeting Kupffer cells (KC) or endothelial cells and associated or not with the parasite CT activity. We also show that the primary role of CT is to inhibit sporozoite clearance by KC during locomotion inside the sinusoid lumen, before crossing the barrier. By being involved in multiple steps of the sporozoite journey from the skin to the final hepatocyte, the parasite proteins mediating host CT emerge as ideal antibody targets for vaccination against the parasite.
Editor: United States: Rockefeller University Press
Idioma: Inglês

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Role of host cell traversal by the malaria sporozoite during liver infection

Tavares, Joana ; Formaglio, Pauline ; Thiberge, Sabine ; Mordelet, Elodie ; Van Rooijen, Nico ; Medvinsky, Alexander ; Ménard, Robert ; Amino, Rogerio

United States: Rockefeller University Press

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