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Dynamic contrast-enhanced computed tomography in 11 dogs with orofacial tumors

Mortier, Jeremy R ; Maddox, Thomas W ; Blackwood, Laura ; La Fontaine, Matthew D ; Busoni, Valeria

American journal of veterinary research, 2023-05, Vol.84 (5), p.1-7 [Periódico revisado por pares]

United States: American Veterinary Medical Association

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Título:
Dynamic contrast-enhanced computed tomography in 11 dogs with orofacial tumors
Autor: Mortier, Jeremy R ; Maddox, Thomas W ; Blackwood, Laura ; La Fontaine, Matthew D ; Busoni, Valeria
Assuntos: Animals ; Blood Volume ; Blood Volume - physiology ; Carcinoma, Squamous Cell ; Carcinoma, Squamous Cell - blood supply ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - veterinary ; Dog Diseases ; Dog Diseases - diagnostic imaging ; Dogs ; General Medicine ; General Veterinary ; Life sciences ; Médecine vétérinaire & santé animale ; Sarcoma ; Sarcoma - diagnostic imaging ; Sarcoma - veterinary ; Sciences du vivant ; Tomography, X-Ray Computed ; Tomography, X-Ray Computed - methods ; Tomography, X-Ray Computed - veterinary ; Veterinary (all) ; Veterinary medicine & animal health
É parte de: American journal of veterinary research, 2023-05, Vol.84 (5), p.1-7
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
scopus-id:2-s2.0-85159242750
Descrição: Treatment of orofacial tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast-enhanced computed tomography (DCECT) can be used to assess tumor perfusion. The objectives of this study were to describe the perfusion parameters of different types of orofacial tumors and to describe the changes in perfusion parameters during radiotherapy (RT) in a subset of them. 11 dogs with orofacial tumors prospectively recruited. All dogs had baseline DCECT to assess blood volume (BV), blood flow (BF), and transit time (TT). Five dogs had repeat DCECT during megavoltage RT. 5 squamous cell carcinomas, 3 sarcomas, 1 melanoma, 1 histiocytic sarcoma, and 1 acanthomatous ameloblastoma were included. Blood volume and BF were higher in squamous cell carcinomas than in sarcomas, although no statistical analysis was performed. At repeat DCECT, 4 dogs showed a reduction in the size of their tumor during RT. Among these dogs, 3 showed an increase in BV and BF and 1 a decrease in these parameters between the baseline and the follow-up DCECT. The only dog whose tumor increased in size between the first and the second DCECT showed a decrease in BV and BF. Perfusion parameters derived from DCECT were described in a series of dogs with various types of orofacial tumors. The results suggest that epithelial tumors could have higher BV and BF than mesenchymal tumors, although larger sample sizes are needed to support these preliminary findings.
Editor: United States: American Veterinary Medical Association
Idioma: Inglês

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Dynamic contrast-enhanced computed tomography in 11 dogs with orofacial tumors

Mortier, Jeremy R ; Maddox, Thomas W ; Blackwood, Laura ; La Fontaine, Matthew D ; Busoni, Valeria

United States: American Veterinary Medical Association

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