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The significance of TNF-alpha gene polymorphisms in preterm delivery

Drews-Piasecka, Elzbieta ; Seremak-Mrozikiewicz, Agnieszka ; Barlik, Magdalena ; Kurzawińska, Grazyna ; Wolski, Hubert ; Woyciechowska, Anzelma ; Czerny, Bogusław ; Drews, Krzysztof

Ginekologia polska, 2014-06, Vol.85 (6), p.428-434 [Periódico revisado por pares]

Poland: Wydawnictwo Via Medica

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  • Título:
    The significance of TNF-alpha gene polymorphisms in preterm delivery
  • Autor: Drews-Piasecka, Elzbieta ; Seremak-Mrozikiewicz, Agnieszka ; Barlik, Magdalena ; Kurzawińska, Grazyna ; Wolski, Hubert ; Woyciechowska, Anzelma ; Czerny, Bogusław ; Drews, Krzysztof
  • Assuntos: Adult ; Alleles ; European Continental Ancestry Group - genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Gestational Age ; Haplotypes ; Humans ; Mutation Rate ; Poland ; Polymorphism, Genetic ; Pregnancy ; Premature Birth - genetics ; Risk Factors ; Tumor Necrosis Factor-alpha - genetics ; Young Adult
  • É parte de: Ginekologia polska, 2014-06, Vol.85 (6), p.428-434
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Nowadays the strong genetic background of preterm delivery (PTD) in connection with immune answer has been indicated. The purpose of the study was the assessment of frequency of TNF-alpha -238G>A, -308G>A, -376G>A gene polymorphisms in the etiology of preterm delivery The study group consisted of 150 women with PTD (22+0 - 36+6 gw.), the controls of 150 women who delivered at term (> 37 gw). PTD group was divided into subgroups: a/delivery between 22-28 gw, b/28-32 gw., and c/32-36+6 gw. Genetic analysis was performed by PCR/RLFP method. Overrepresentation of -238GA genotype (12.7 vs. 4.7%, p = 0.011) and -238A allele (7.7 vs. 2.3%, p = 0.002) in PTD group has been observed. In PTD 28-32 gw. subgroup, higher frequency of -238GA genotype (31.6 vs. 4.7%, p = 0.00095), and mutated -238A allele (21.1 vs. 2.3%, p = 0.00004) was noted. Moreover in PTD 28-32 gw. subgroup we have noted higher presence of heterozygous -376GA genotype (10.5 vs. 1.3%, p = 0.063) and mutated -376A allele (5.3 vs. 0.7%, p = 0.064). Analysis of TNF-alpha polymorphisms co-occurrence showed statistically significant overrepresentation of genotypes containing mutated -238A allele in PTD group (-238GA/-308GG/-376GG: 8.0 vs. 2.7%, p = 0.035). Haplotype analysis revealed statistically significant difference between PTD and controls in the incidence of -376G/-308G/-238A haplotype containing mutated -238A allele (0.063067 vs. 0.016634, p = 0.030). The study indicated the strong association of mutated -238A allele of TNF-alpha gene with increased risk of PTD. Analysis of genotypes and alleles prevalence in PTD women divided according to gestational age suggests the possible role of mutated variants of -238G>A and -376G>A TNF-alpha polymorphisms in Polish women delivering between 28 and 32 gw.
  • Editor: Poland: Wydawnictwo Via Medica
  • Idioma: Inglês;Polonês
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