skip to main content
Idioma:

Locus ceruleus lesions block pulsatile LH release in ovariectomized rats

Anselmo-Franci, J.A. ; Rocha-Barros, V.M. ; Franci, C.R. ; McCann, S.M.

Brain research, 1999-06, Vol.833 (1), p.86-92 [Periódico revisado por pares]

London: Elsevier B.V

Texto completo disponível

Citações Citado por
  • Título:
    Locus ceruleus lesions block pulsatile LH release in ovariectomized rats
  • Autor: Anselmo-Franci, J.A. ; Rocha-Barros, V.M. ; Franci, C.R. ; McCann, S.M.
  • Assuntos: Animals ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Locus coeruleus ; Locus Coeruleus - pathology ; Locus Coeruleus - physiology ; Luteinizing hormone ; Luteinizing Hormone - blood ; Luteinizing Hormone - metabolism ; Ovariectomy ; Pulsatile Flow ; Pulsatile secretion ; Rats ; Rats, Wistar ; Vertebrates: endocrinology
  • É parte de: Brain research, 1999-06, Vol.833 (1), p.86-92
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-1
    content type line 23
    ObjectType-Article-1
    ObjectType-Feature-2
  • Descrição: Luteinizing hormone (LH) secretion during the reproductive cycle and in ovariectomized (OVX) rats is pulsatile and this pattern of secretion is determined by intermittent discharges of LH-releasing hormone (LHRH) into the hypophysial portal vessels. LHRH secretion is probably controlled by prior pulsatile norepinephrine (NE) release. The locus ceruleus (LC) is an important source of NE to the LHRH neurons. We have shown previously that LC lesions block the preovulatory LH surge and ovulation and also cause a decrease in plasma LH concentrations in OVX rats. The possible role of the LC in regulating pulsatile LH release has not been explored. Therefore, the aim of this work was to investigate, in OVX rats, the effects of LC lesions on pulsatile LH secretion. LC lesions were produced in adult female rats three weeks after OVX. On the next morning, the jugular vein was catheterized and, on the afternoon of the same day, blood samples (0.3 ml) were withdrawn every 5 min, during 90 min, from conscious freely moving rats. Plasma LH was measured by radioimmunoassay. LC lesions greatly suppressed pulsatile LH secretion by decreasing both LH pulse frequency and amplitude. The basal as well as total secretion of LH were also decreased. This inhibitory effect of the lesions was observed only when at least 50% of the nucleus was destroyed. Data from sham-operated animals as well as those with less than 50% destruction of the LC did not differ from those of the control rats without brain lesions. Since LC lesions induce a decrease in NE content in the preoptic area and median eminence, the inhibition of pulsatile LH release in ovariectomized rats with LC lesions occurs presumably as result of decreased pulsatile NE release into these areas of the brain that decreases both the frequency and the amount of LHRH released per pulse.
  • Editor: London: Elsevier B.V
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.