skip to main content
Idioma:

Vitamin D status and outcomes for hospitalised older patients with COVID-19

Baktash, Vadir ; Hosack, Tom ; Patel, Nishil ; Shah, Shital ; Kandiah, Pirabakaran ; Van den Abbeele, Koenraad ; Mandal, Amit K J ; Missouris, Constantinos G

Postgraduate medical journal, 2021-07, Vol.97 (1149), p.442-447 [Periódico revisado por pares]

England: BMJ Publishing Group

Texto completo disponível

Citações Citado por
  • Título:
    Vitamin D status and outcomes for hospitalised older patients with COVID-19
  • Autor: Baktash, Vadir ; Hosack, Tom ; Patel, Nishil ; Shah, Shital ; Kandiah, Pirabakaran ; Van den Abbeele, Koenraad ; Mandal, Amit K J ; Missouris, Constantinos G
  • Assuntos: Original Research
  • É parte de: Postgraduate medical journal, 2021-07, Vol.97 (1149), p.442-447
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: PurposeOlder adults are more likely to be vitamin D deficient. The aim of the study was to determine whether these patients have worse outcomes with COVID-19.MethodsWe conducted a prospective cohort study between 1 March and 30 April 2020 to assess the importance of vitamin D deficiency in older patients with COVID-19. The cohort consisted of patients aged ≥65 years presenting with symptoms consistent with COVID-19 (n=105). All patients were tested for serum 25-hydroxyvitamin D (25(OH)D) levels during acute illness. Diagnosis of COVID-19 was confirmed via viral reverse transcriptase PCR swab or supporting radiological evidence. COVID-19-positive arm (n=70) was sub-divided into vitamin D-deficient (≤30 nmol/L) (n=39) and -replete groups (n=35). Subgroups were assessed for disease severity using biochemical, radiological and clinical markers. Primary outcome was in-hospital mortality. Secondary outcomes were laboratory features of cytokine storm, thoracic imaging changes and requirement of non-invasive ventilation (NIV).ResultsCOVID-19-positive arm demonstrated lower median serum 25(OH)D level of 27 nmol/L (IQR=20–47 nmol/L) compared with COVID-19-negative arm, with median level of 52 nmol/L (IQR=31.5–71.5 nmol/L) (p value=0.0008). Among patients with vitamin D deficiency, there was higher peak D-dimer level (1914.00 μgFEU/L vs 1268.00 μgFEU/L) (p=0.034) and higher incidence of NIV support and high dependency unit admission (30.77% vs 9.68%) (p=0.042). No increased mortality was observed between groups.ConclusionOlder adults with vitamin D deficiency and COVID-19 may demonstrate worse morbidity outcomes. Vitamin D status may be a useful prognosticator.
  • Editor: England: BMJ Publishing Group
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  8 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.