Idioma:

Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells

Ye, Jody ; Vives-Pi, Marta ; Gillespie, Kathleen M Maedler, Kathrin

PloS one, 2014-01, Vol.9 (1), p.e86985-e86985 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells
Autor: Ye, Jody ; Vives-Pi, Marta ; Gillespie, Kathleen M
Maedler, Kathrin
Assuntos: Adolescent ; Adult ; Age ; Antigens ; Apoptosis ; Autoimmune diseases ; Autoimmunity ; Autoimmunity - genetics ; Autoimmunity - immunology ; Beta cells ; Biology ; Child ; Child, Preschool ; Chimerism ; Chromosomes, Human, X - genetics ; Chromosomes, Human, X - immunology ; Chromosomes, Human, Y - genetics ; Chromosomes, Human, Y - immunology ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - metabolism ; Diabetes therapy ; Effector cells ; Ethanol ; Female ; Fluorescence ; GATA4 Transcription Factor - immunology ; GATA4 Transcription Factor - metabolism ; Humans ; Hybridization ; Identification methods ; Immune response ; Immune system ; Immunofluorescence ; Immunology ; In Situ Hybridization, Fluorescence - methods ; Infant ; Insulin ; Insulin - immunology ; Insulin - metabolism ; Islet cells ; Islets of Langerhans ; Islets of Langerhans - immunology ; Islets of Langerhans - metabolism ; Ki-67 Antigen - immunology ; Ki-67 Antigen - metabolism ; Male ; Maternal-Fetal Exchange - genetics ; Maternal-Fetal Exchange - immunology ; Medicine ; Metabolism ; Microscopy, Confocal ; Microscopy, Fluorescence ; Pancreas ; Pancreas - embryology ; Pancreas - immunology ; Pancreas - metabolism ; Placenta ; Pregnancy ; Repair ; Replicating ; Rodents ; Transcription factors ; Type 1 diabetes ; Young Adult
É parte de: PloS one, 2014-01, Vol.9 (1), p.e86985-e86985
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceived and designed the experiments: JY KMG. Performed the experiments: JY KMG. Analyzed the data: JY KG. Contributed reagents/materials/analysis tools: MV-P. Wrote the paper: JY MV-P KMG.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Maternal microchimeric cells (MMc) transfer across the placenta during pregnancy. Increased levels of MMc have been observed in several autoimmune diseases including type 1 diabetes but their role is unknown. It has been suggested that MMc are 1) effector cells of the immune response, 2) targets of the autoimmune response or 3) play a role in tissue repair. The aim of this study was to define the cellular phenotype of MMc in control (n = 14) and type 1 diabetes pancreas (n = 8). Using sex chromosome-based fluorescence in-situ hybridization, MMc were identified in male pancreas and their phenotype determined by concomitant immunofluorescence. In normal pancreas, MMc positive for endocrine, exocrine, duct and acinar markers were identified suggesting that these cells are derived from maternal progenitors. Increased frequencies of MMc were observed in type 1 diabetes pancreas (p = 0.03) with particular enrichment in the insulin positive fraction (p = 0.01). MMc did not contribute to infiltrating immune cells or Ki67+ islet cell populations in type 1 diabetes. These studies provide support for the hypothesis that MMc in human pancreas are derived from pancreatic precursors. Increased frequencies of MMc beta cells may contribute to the initiation of autoimmunity or to tissue repair but do not infiltrate islets in type 1 diabetes.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells

Ye, Jody ; Vives-Pi, Marta ; Gillespie, Kathleen M Maedler, Kathrin

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.