skip to main content
Idioma:
Primo Advanced Search
Primo Advanced Search Query Term
Primo Advanced Search Query Term
Primo Advanced Search Query Term
Primo Advanced Search prefilters
Busca Simples

High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and β-Lactamase Encoding Genes in a Brazilian Intensive Care Unit

Ferreira, Roumayne L ; da Silva, Brenda C M ; Rezende, Graziela S ; Nakamura-Silva, Rafael ; Pitondo-Silva, André ; Campanini, Emeline Boni ; Brito, Márcia C A ; da Silva, Eulália M L ; Freire, Caio César de Melo ; da Cunha, Anderson F ; Pranchevicius, Maria-Cristina da Silva

Frontiers in microbiology, 2019-01, Vol.9, p.3198-3198 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

Texto completo disponível

Citações Citado por
  • Título:
    High Prevalence of Multidrug-Resistant Klebsiella pneumoniae Harboring Several Virulence and β-Lactamase Encoding Genes in a Brazilian Intensive Care Unit
  • Autor: Ferreira, Roumayne L ; da Silva, Brenda C M ; Rezende, Graziela S ; Nakamura-Silva, Rafael ; Pitondo-Silva, André ; Campanini, Emeline Boni ; Brito, Márcia C A ; da Silva, Eulália M L ; Freire, Caio César de Melo ; da Cunha, Anderson F ; Pranchevicius, Maria-Cristina da Silva
  • Assuntos: intensive care units ; Klebsiella pneumoniae ; Microbiology ; multi-drug resistance ; virulence genes ; β-lactams gene
  • É parte de: Frontiers in microbiology, 2019-01, Vol.9, p.3198-3198
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Edited by: Gilberto Igrejas, University of Trás-os-Montes and Alto Douro, Portugal
    These authors have contributed equally to this work
    Reviewed by: Jayapradha R., SASTRA University, India; Jianmin Zhang, South China Agricultural University, China
    This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
  • Descrição: is an important opportunistic pathogen that commonly causes nosocomial infections and contributes to substantial morbidity and mortality. We sought to investigate the antibiotic resistance profile, pathogenic potential and the clonal relationships between ( = 25) isolated from patients and sources at a tertiary care hospital's intensive care units (ICUs) in the northern region of Brazil. Most of isolates ( = 21, 84%) were classified as multidrug resistant (MDR) with high-level resistance to β-lactams, aminoglycosides, quinolones, tigecycline, and colistin. All the 25 isolates presented extended-spectrum beta-lactamase-producing (ESBL), including carbapenemase producers, and carried the (100%), (100%), variants ( = 24, 96%), group ( = 21, 84%) and group ( = 18, 72%) genes. The K2 serotype was found in 4% ( = 1) of the isolates, and the K1 was not detected. The virulence-associated genes found among the 25 isolates were D ( = 24, 96%), H-1 ( = 22, 88%), B (100%), A ( = 10, 40%), S ( = 15, 60%). The genes related with efflux pumps and outer membrane porins found were (100%), C ( = 24, 96%), K ( = 22, 88%), K35 ( = 15, 60%), and K36 ( = 7, 28%). ERIC-PCR was employed to determine the clonal relationship between the different isolated strains. The obtained ERIC-PCR patterns revealed that the similarity between isolates was above 70%. To determine the sequence types (STs) a multilocus sequence typing (MLST) assay was used. The results indicated the presence of high-risk international clones among the isolates. In our study, the wide variety of MDR harboring β-lactams and virulence genes strongly suggest a necessity for the implementation of effective strategies to prevent and control the spread of antibiotic resistant infections.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  10 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.