skip to main content
Idioma:

3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis

Cho, Sun Hee ; Lee, Soonchul ; Kim, Jeong In

Scientific reports, 2024-03, Vol.14 (1), p.7365-7365, Article 7365 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por
  • Título:
    3D cotton-type anisotropic biomimetic scaffold with low fiber motion electrospun via a sharply inclined array collector for induced osteogenesis
  • Autor: Cho, Sun Hee ; Lee, Soonchul ; Kim, Jeong In
  • Assuntos: 3D fibers ; Biomimetic scaffolds ; Biomimetics ; Bone tissue engineering ; Bones ; Cell adhesion ; Cell differentiation ; Cell migration ; Cell Proliferation ; Cottony fibers ; Electrospinning ; Extracellular matrix ; Fibers ; Infiltration ; Osteogenesis ; Polyesters - chemistry ; Porosity ; Tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry ; Topography
  • É parte de: Scientific reports, 2024-03, Vol.14 (1), p.7365-7365, Article 7365
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Electrospinning is an effective method to fabricate fibrous scaffolds that mimic the ECM of bone tissue on a nano- to macro-scale. However, a limitation of electrospun fibrous scaffolds for bone tissue engineering is the structure formed by densely compacted fibers, which significantly impedes cell infiltration and tissue ingrowth. To address this problem, several researchers have developed numerous techniques for fabricating 3D fibrous scaffolds with customized topography and pore size. Despite the success in developing various 3D electrospun scaffolds based on fiber repulsion, the lack of contact points between fibers in those scaffolds has been shown to hinder cell attachment, migration, proliferation, and differentiation due to excessive movement of the fibers. In this article, we introduce a Dianthus caryophyllus-inspired scaffold fabricated using SIAC-PE, a modified collector under specific viscosity conditions of PCL/LA solution. The developed scaffold mimicking the structural similarities of the nature-inspired design presented enhanced cell proliferation, infiltration, and increased expression of bone-related factors by reducing fiber movements, presenting high space interconnection, high porosity, and controlled fiber topography.
  • Editor: England: Nature Publishing Group
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.