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Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging

Beckers, Nicole G.M. ; Macklon, Nicholas S. ; Eijkemans, Marinus J.C. ; Fauser, Bart C.J.M.

Fertility and sterility, 2002-08, Vol.78 (2), p.291-297 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging
Autor: Beckers, Nicole G.M. ; Macklon, Nicholas S. ; Eijkemans, Marinus J.C. ; Fauser, Bart C.J.M.
Assuntos: Adult ; Biological and medical sciences ; Female ; Fertilization in Vitro ; Follicle Stimulating Hormone - blood ; follicles ; follicular phase ; Follicular Phase - physiology ; FSH ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; inhibin ; Inhibins - blood ; IVF ; Mammalian female genital system ; menstrual cycle ; Ovarian aging ; Ovarian Follicle - physiology ; ovary ; Ovary - physiology ; poor response ; progesterone ; Prospective Studies ; Vertebrates: reproduction
É parte de: Fertility and sterility, 2002-08, Vol.78 (2), p.291-297
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Objective: To investigate whether follicular phase characteristics associated with ovarian aging can be observed in women of normal reproductive age, who had previously shown a poor response to ovarian hyperstimulation for IVF. Design: Observational, prospective study. Setting: Tertiary fertility center. Patient(s): Eleven regularly cycling, ovulatory women, aged 29–40 years who previously presented with fewer than four dominant follicles after ovarian hyperstimulation for IVF. Intervention(s): Frequent serum hormone assessments and transvaginal ultrasound during the follicular phase of a spontaneous, unstimulated cycle. Main Outcome Measure(s): Duration of the follicular phase; serum LH, FSH, E 2, P, inhibin A, and inhibin B levels; and number of antral follicles observed by ultrasound. Results were compared with the cycle characteristics of a reference population of 38 healthy normo-ovulatory women aged 20–36 years (as published elsewhere). Result(s): Poor responders had significantly fewer antral follicles than controls. Median FSH concentrations were significantly higher compared with controls, but the majority had FSH levels within the normal range. Follicular phase P levels were significantly higher in poor responders. Duration of the follicular phase, E 2, and inhibin A and inhibin B serum levels did not differ between poor responders and controls. Conclusion(s): Normo-ovulatory regularly cycling women with a previous poor response to ovarian hyperstimulation for IVF show follicular phase characteristics suggestive of ovarian aging.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging

Beckers, Nicole G.M. ; Macklon, Nicholas S. ; Eijkemans, Marinus J.C. ; Fauser, Bart C.J.M.

New York, NY: Elsevier Inc

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