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α-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase

LIMBERG, Jacqueline K ; ELDRIDGE, Marlowe W ; PROCTOR, Lester T ; SEBRANEK, Joshua J ; SCHRAGE, William G

Journal of applied physiology (1985), 2010-11, Vol.109 (5), p.1360-1368 [Periódico revisado por pares]

Bethesda, MD: American Physiological Society

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Título:
α-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase
Autor: LIMBERG, Jacqueline K ; ELDRIDGE, Marlowe W ; PROCTOR, Lester T ; SEBRANEK, Joshua J ; SCHRAGE, William G
Assuntos: Adrenergic alpha-Agonists - administration & dosage ; Adult ; Biological and medical sciences ; Blood Flow Velocity ; Brachial Artery - diagnostic imaging ; Brachial Artery - drug effects ; Brachial Artery - innervation ; Exercise ; Female ; Follicular Phase ; Forearm - blood supply ; Fundamental and applied biological sciences. Psychology ; Humans ; Infusions, Intra-Arterial ; Luteal Phase ; Male ; Menstrual Cycle ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, alpha - metabolism ; Regional Blood Flow ; Sex Factors ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - metabolism ; Ultrasonography ; Vasoconstriction - drug effects ; Vasoconstrictor Agents - administration & dosage ; Vasodilation - drug effects ; Vasodilator Agents - administration & dosage ; Young Adult
É parte de: Journal of applied physiology (1985), 2010-11, Vol.109 (5), p.1360-1368
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Sex differences exist in autonomic control of the cardiovascular system. This study was designed to directly test sex or female menstrual phase-related differences in α-adrenergic control of blood flow during exercise. We hypothesized that women would exhibit reduced α-adrenergic vasoconstriction compared with men during exercise; in addition, women would constrict less during the early luteal than the early follicular phase of the female menses. Young men (n = 10) were studied once and women (n = 9) studied twice, once during the early follicular phase and once during the early luteal phase of female menses. We measured forearm blood flow (FBF; Doppler ultrasound of the brachial artery) during rest and steady-state dynamic exercise (15 and 30% of maximal voluntary contraction, 20 contractions/min). A brachial artery catheter was inserted for the local administration of α-adrenergic agonists [phenylephrine (PE; α(1)) or clonidine (CL; α(2))]. Blood flow responses to exercise [forearm vascular conductance (FVC)] were similar between all groups. At rest, infusion of PE or CL decreased FVC in all groups (40-60% reduction). Vasoconstriction to PE was abolished in all groups at 15 and 30% exercise intensity. Vasoconstriction to CL was reduced at 15% and abolished at 30% intensity in all groups; women had less CL-induced constriction during the early luteal than early follicular phase (P < 0.017, 15% intensity). These results indicate that vasodilator responses to forearm exercise are comparable between men and women and are achieved through similar paths of α-adrenergic vascular control at moderate intensities; this control may differ at low intensities specific to the female menstrual phase.
Editor: Bethesda, MD: American Physiological Society
Idioma: Inglês

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α-Adrenergic control of blood flow during exercise: effect of sex and menstrual phase

LIMBERG, Jacqueline K ; ELDRIDGE, Marlowe W ; PROCTOR, Lester T ; SEBRANEK, Joshua J ; SCHRAGE, William G

Bethesda, MD: American Physiological Society

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