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Liposome: classification, preparation, and applications

Akbarzadeh, Abolfazl ; Rezaei-Sadabady, Rogaie ; Davaran, Soodabeh ; Joo, Sang Woo ; Zarghami, Nosratollah ; Hanifehpour, Younes ; Samiei, Mohammad ; Kouhi, Mohammad ; Nejati-Koshki, Kazem

Nanoscale research letters, 2013-02, Vol.8 (1), p.102-102, Article 102 [Periódico revisado por pares]

New York: Springer New York

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  • Título:
    Liposome: classification, preparation, and applications
  • Autor: Akbarzadeh, Abolfazl ; Rezaei-Sadabady, Rogaie ; Davaran, Soodabeh ; Joo, Sang Woo ; Zarghami, Nosratollah ; Hanifehpour, Younes ; Samiei, Mohammad ; Kouhi, Mohammad ; Nejati-Koshki, Kazem
  • Assuntos: Chemistry and Materials Science ; Materials Science ; Molecular Medicine ; Nano Review ; Nanochemistry ; Nanoscale Science and Technology ; Nanotechnology ; Nanotechnology and Microengineering
  • É parte de: Nanoscale research letters, 2013-02, Vol.8 (1), p.102-102, Article 102
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid-60s. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology. Since then, liposomes have made their way to the market. Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to ‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.
  • Editor: New York: Springer New York
  • Idioma: Inglês
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