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Dietary phylloquinone depletion and repletion in postmenopausal women effects on bone and mineral metabolism

Lígia Araújo Martini Sarah L Booth; E Saltzman; Maria do Rosário Dias de Oliveira Latorre; R. J Wood

Osteoporosis International London v. 17, n. 6, p. 929-935, 2006

London 2006

Localização: FSP - Faculdade de Saúde Pública    (HNT-02/2006 )(Acessar)

  • Título:
    Dietary phylloquinone depletion and repletion in postmenopausal women effects on bone and mineral metabolism
  • Autor: Lígia Araújo Martini
  • Sarah L Booth; E Saltzman; Maria do Rosário Dias de Oliveira Latorre; R. J Wood
  • Assuntos: VITAMINA K; DENSITOMETRIA ÓSSEA; COMPOSTOS INORGÂNICOS (METABOLISMO); MENOPAUSA (METABOLISMO); MULHERES
  • É parte de: Osteoporosis International London v. 17, n. 6, p. 929-935, 2006
  • Descrição: Introduction Vitamin K has been implicated in increased bone fracture risk. Despite a potential role of vitamin K in bone, little is known about the effects of altered dietary phylloquinone intake on the underlying components of bone and mineral metabolism. Methods A 84-day in-house dietary phylloquinone (vitamin K) depletion-repletion study was undertaken in 21 postmenopausal women (mean age: 70 years) to assess the effects of altered vitamin K status on intestinal calcium (Ca) absorption, urinary and serum Ca and phosphorus (P), serum calcemic hormones, and serum biomarkers of bone turnover [osteocalcin and N-telopeptide type 1 collagen cross-links (NTx)] and the response to 1,25-dihydroxyvitamin D treatment (1 ug/day 7 d). Results The group receiving calcitriol treatment (n=11) had higher Ca absorption, urinary Ca, urinary and serum P and serum osteocalcin and lower serum parathyroid hormone (PTH).There were no significant effects of acute (4-week) phylloquinone depletion on response to 1,25-dihydroxyvitamin D treatment or on measures of bone formation or mineral metabolism. However, phylloquinone treatment had a significant effect (p< 0.01). Conclusions These findings suggest that altering vitamin K status in postmenopausal women by manipulating phylloquinone intake does not have an acute affect on intestinal Ca absorption, renal mineral excretion, or bone formation, but high phylloquinone intake may modestly reduce bone resorption. The impact of high
    phylloquinone intake on bone mineral density and fracture risk needs to be ascertained in randomized clinical trials
  • Editor: London
  • Data de criação/publicação: 2006
  • Formato: p. 929-935.
  • Idioma: Inglês
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