Idioma:

Alteration in the mRNA expression profile of the autophagy-related mTOR pathway in schizophrenia patients treated with olanzapine

Cui, Fengwei ; Gu, Shuguang ; Gu, Yue ; Yin, Jiajun ; Fang, Chunxia ; Liu, Liang

BMC psychiatry, 2021-08, Vol.21 (1), p.388-388, Article 388 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Alteration in the mRNA expression profile of the autophagy-related mTOR pathway in schizophrenia patients treated with olanzapine
Autor: Cui, Fengwei ; Gu, Shuguang ; Gu, Yue ; Yin, Jiajun ; Fang, Chunxia ; Liu, Liang
Assuntos: Age ; Antidepressants ; Antipsychotics ; Autophagy ; Autophagy (Cytology) ; Autophagy-Related Proteins ; Birds of prey ; Cell cycle ; Cellular signal transduction ; Complications and side effects ; DEPTOR ; Drug dosages ; Drug therapy ; Electroconvulsive therapy ; Extrapyramidal system ; Females ; Gene expression ; Genetic aspects ; Health aspects ; Humans ; Intracellular Signaling Peptides and Proteins ; Kinases ; Mental disorders ; Messenger RNA ; mRNA expression ; mTOR pathway ; Olanzapine ; Olanzapine - therapeutic use ; Pathogenesis ; Patients ; Phagocytosis ; Protein kinases ; Proteins ; Psychiatry ; Psychotropic drugs ; Rapamycin ; Rapamycin-Insensitive Companion of mTOR Protein ; Regulatory-Associated Protein of mTOR ; RNA, Messenger - genetics ; Schizophrenia ; Schizophrenia - drug therapy ; Schizophrenia - genetics ; Signal transduction ; Sirolimus ; TOR protein ; TOR Serine-Threonine Kinases - genetics
É parte de: BMC psychiatry, 2021-08, Vol.21 (1), p.388-388, Article 388
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The mammalian target of rapamycin protein (mTOR) signaling pathway is involved in the pathogenesis of schizophrenia and the mechanism of extrapyramidal adverse reactions to antipsychotic drugs, which might be mediated by an mTOR-dependent autophagy impairment. This study aimed to examine the expression of mTOR pathway genes in patients with schizophrenia treated with olanzapine, which is considered an mTOR inhibitor and autophagy inducer. Thirty-two patients with acute schizophrenia who had been treated with olanzapine for four weeks (average dose 14.24 ± 4.35 mg/d) and 32 healthy volunteers were recruited. Before and after olanzapine treatment, the Positive and Negative Syndrome Scale (PANSS) was used to evaluate the symptoms of patients with schizophrenia, and the mRNA expression levels of mTOR pathway-related genes, including MTOR, RICTOR, RAPTOR, and DEPTOR, were detected in fasting venous blood samples from all subjects using real-time quantitative PCR. The MTOR and RICTOR mRNA expression levels in patients with acute schizophrenia were significantly decreased compared with those of healthy controls and further significantly decreased after four weeks of olanzapine treatment. The DEPTOR mRNA expression levels in patients with acute schizophrenia were not significantly different from those of healthy controls but were significantly increased after treatment. The expression levels of the RAPTOR mRNA were not significantly different among the three groups. The pairwise correlations of MTOR, DEPTOR, RAPTOR, and RICTOR mRNA expression levels in patients with acute schizophrenia and healthy controls were significant. After olanzapine treatment, the correlations between the expression levels of the DEPTOR and MTOR mRNAs and between the DEPTOR and RICTOR mRNAs disappeared. Abnormalities in the mTOR pathway, especially DEPTOR and mTORC2, might play important roles in the autophagy mechanism underlying the pathophysiology of schizophrenia and effects of olanzapine treatment.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Alteration in the mRNA expression profile of the autophagy-related mTOR pathway in schizophrenia patients treated with olanzapine

Cui, Fengwei ; Gu, Shuguang ; Gu, Yue ; Yin, Jiajun ; Fang, Chunxia ; Liu, Liang

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.