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Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

Mitchell, Khadijah A ; Nichols, Noah ; Tang, Wei ; Walling, Jennifer ; Stevenson, Holly ; Pineda, Marbin ; Stefanescu, Roxana ; Edelman, Daniel C ; Girvin, Andrew T ; Zingone, Adriana ; Sinha, Sanju ; Bowman, Elise ; Rossi, Emily L ; Arauz, Rony F ; Jack Zhu, Yuelin ; Lack, Justin ; Weingartner, Elizabeth ; Waterfall, Joshua J ; Pine, Sharon R ; Simmons, John ; Meltzer, Paul ; Ryan, Bríd M

Nature communications, 2019-12, Vol.10 (1), p.5735-7, Article 5735 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
Autor: Mitchell, Khadijah A ; Nichols, Noah ; Tang, Wei ; Walling, Jennifer ; Stevenson, Holly ; Pineda, Marbin ; Stefanescu, Roxana ; Edelman, Daniel C ; Girvin, Andrew T ; Zingone, Adriana ; Sinha, Sanju ; Bowman, Elise ; Rossi, Emily L ; Arauz, Rony F ; Jack Zhu, Yuelin ; Lack, Justin ; Weingartner, Elizabeth ; Waterfall, Joshua J ; Pine, Sharon R ; Simmons, John ; Meltzer, Paul ; Ryan, Bríd M
Assuntos: Adenocarcinoma ; Adenocarcinoma of Lung - genetics ; African Americans - genetics ; Aged ; Case-Control Studies ; DNA Mutational Analysis ; Etiology ; European Continental Ancestry Group - genetics ; Female ; Health Status Disparities ; Humans ; Interleukin-6 - metabolism ; Janus kinase 2 ; Janus Kinase 2 - genetics ; Lung cancer ; Lung Neoplasms - genetics ; Male ; MicroRNAs - metabolism ; Middle Aged ; Minority & ethnic groups ; Mutation ; Population studies ; Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics ; Signal Transduction - genetics ; STAT3 Transcription Factor - metabolism
É parte de: Nature communications, 2019-12, Vol.10 (1), p.5735-7, Article 5735
Descrição: Reducing or eliminating persistent disparities in lung cancer incidence and survival has been challenging because our current understanding of lung cancer biology is derived primarily from populations of European descent. Here we show results from a targeted sequencing panel using NCI-MD Case Control Study patient samples and reveal a significantly higher prevalence of PTPRT and JAK2 mutations in lung adenocarcinomas among African Americans compared with European Americans. This increase in mutation frequency was validated with independent WES data from the NCI-MD Case Control Study and TCGA. We find that patients carrying these mutations have a concomitant increase in IL-6/STAT3 signaling and miR-21 expression. Together, these findings suggest the identification of these potentially actionable mutations could have clinical significance for targeted therapy and the enrollment of minority populations in clinical trials.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

England: Nature Publishing Group

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