Idioma:

1,25‐Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen‐presenting cells

Khoo, Ai‐Leng ; Joosten, Irma ; Michels, Meta ; Woestenenk, Rob ; Preijers, Frank ; He, Xue‐Hui ; Netea, Mihai G. ; van der Ven, André J. A. M. ; Koenen, Hans J. P. M.

Immunology, 2011-12, Vol.134 (4), p.459-468 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
1,25‐Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen‐presenting cells
Autor: Khoo, Ai‐Leng ; Joosten, Irma ; Michels, Meta ; Woestenenk, Rob ; Preijers, Frank ; He, Xue‐Hui ; Netea, Mihai G. ; van der Ven, André J. A. M. ; Koenen, Hans J. P. M.
Assuntos: 1,25‐dihydroxyvitamin D3 ; Antigen Presentation - drug effects ; Antigen Presentation - immunology ; Antigen-Presenting Cells - drug effects ; Antigen-Presenting Cells - immunology ; Cell growth ; Cell Proliferation - drug effects ; Cells, Cultured ; cholecalciferol ; forkhead box protein 3 ; HIV ; HIV Infections - complications ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; immunomodulation ; Interleukin-10 - biosynthesis ; Interleukin-10 - immunology ; Interleukin-2 - immunology ; Lymphocyte Activation - drug effects ; Original ; Receptors, Calcitriol - biosynthesis ; Receptors, Calcitriol - immunology ; regulatory T cells ; T cell receptors ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - metabolism ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - immunology ; Vitamin D - pharmacology ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - immunology
É parte de: Immunology, 2011-12, Vol.134 (4), p.459-468
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
Senior author: Dr. H. J. P. M. Koenen
Descrição: Summary Vitamin D3 is known to induce regulatory T (Treg) cells by rendering antigen‐presenting cells tolerogenic, its direct effect on human naturally occurring Treg cells is unclear. Here, we investigated if and how 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3] can directly affect the proliferation and function of human naturally occurring Treg cells in vitro. First, we demonstrated that these Treg cells express vitamin D receptors that were up‐regulated following anti‐CD3/CD28‐bead stimulation. 1,25(OH)2D3 inhibited proliferation of Treg cells even when exogenous interleukin‐2 was provided. Treg cells were more susceptible to the inhibitory effect of 1,25(OH)2D3 than conventional T cells. 1,25(OH)2D3 neither affected the anergic state nor the suppressive function of Treg cells but induced a subtle increase in interleukin‐10‐secreting cells. The cell‐division‐inhibiting effect of 1,25(OH)2D3 on Treg cells was also demonstrated in vivo by supplementing vitamin D‐deficient HIV‐1‐infected patients with 2000 IU cholecalciferol (vitamin D3). Increased serum 1,25(OH)2D3 levels were associated with a drop in the number and percentage of Treg cells, which may be attributed to a decrease in the proliferating Foxp3+ Treg cell population. In conclusion, 1,25(OH)2D3 directly affects Treg cell growth and promotes interleukin‐10 production without apparent effects on activation status and suppressive phenotype whereas in vivo, high serum 1,25(OH)2D3 levels are associated with reduced Treg cell proliferation and a reduced number of Treg cells.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

1,25‐Dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen‐presenting cells

Khoo, Ai‐Leng ; Joosten, Irma ; Michels, Meta ; Woestenenk, Rob ; Preijers, Frank ; He, Xue‐Hui ; Netea, Mihai G. ; van der Ven, André J. A. M. ; Koenen, Hans J. P. M.

Oxford, UK: Blackwell Publishing Ltd

Buscando em bases de dados remotas. Favor aguardar.