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The LOV-domain blue-light receptor LreA of the fungus Alternaria alternata binds predominantly FAD as chromophore and acts as a light and temperature sensor

Schuhmacher, Lars ; Heck, Steffen ; Pitz, Michael ; Mathey, Elena ; Lamparter, Tilman ; Blumhofer, Alexander ; Leister, Kai ; Fischer, Reinhard

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107238-107238, Article 107238 [Periódico revisado por pares]

United States: Elsevier Inc

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The LOV-domain blue-light receptor LreA of the fungus Alternaria alternata binds predominantly FAD as chromophore and acts as a light and temperature sensor
Autor: Schuhmacher, Lars ; Heck, Steffen ; Pitz, Michael ; Mathey, Elena ; Lamparter, Tilman ; Blumhofer, Alexander ; Leister, Kai ; Fischer, Reinhard
Assuntos: Alternaria ; Alternaria - metabolism ; blue-light sensing ; circadian rhythm ; FAD ; flavin chromophore ; Flavin-Adenine Dinucleotide - chemistry ; Flavin-Adenine Dinucleotide - metabolism ; Fungal Proteins - chemistry ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; fungi ; Gene Expression Regulation, Fungal ; Light ; Neurospora crassa ; Photoreceptors, Microbial - chemistry ; Photoreceptors, Microbial - genetics ; Photoreceptors, Microbial - metabolism ; Phytochrome - chemistry ; Phytochrome - genetics ; Phytochrome - metabolism ; Protein Domains ; Reactive Oxygen Species - metabolism ; signal transduction ; Temperature ; temperature sensing ; WC-1
É parte de: The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107238-107238, Article 107238
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Light and temperature sensing are important features of many organisms. Light may provide energy but may also be used by non-photosynthetic organisms for orientation in the environment. Recent evidence suggests that plant and fungal phytochrome and plant phototropin serve dual functions as light and temperature sensors. Here we characterized the fungal LOV-domain blue-light receptor LreA of Alternaria alternata and show that it predominantly contains FAD as chromophore. Blue-light illumination induced ROS production followed by protein agglomeration in vitro. In vivo ROS may control LreA activity. LreA acts as a blue-light photoreceptor but also triggers temperature-shift-induced gene expression. Both responses required the conserved amino acid cysteine 421. We therefore propose that temperature mimics the photoresponse, which could be the ancient function of the chromoprotein. Temperature-dependent gene expression control with LreA was distinct from the response with phytochrome suggesting fine-tuned, photoreceptor-specific gene regulation.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The LOV-domain blue-light receptor LreA of the fungus Alternaria alternata binds predominantly FAD as chromophore and acts as a light and temperature sensor

Schuhmacher, Lars ; Heck, Steffen ; Pitz, Michael ; Mathey, Elena ; Lamparter, Tilman ; Blumhofer, Alexander ; Leister, Kai ; Fischer, Reinhard

United States: Elsevier Inc

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