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Culture media affect sex after IVF treatment—a detailed analysis of explanatory variables

Guldager, T. ; Gabrielsen, A. ; Iversen, L. H. ; Kirkegaard, K.

Journal of assisted reproduction and genetics, 2024-05, Vol.41 (5), p.1181-1191 [Periódico revisado por pares]

New York: Springer US

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  • Título:
    Culture media affect sex after IVF treatment—a detailed analysis of explanatory variables
  • Autor: Guldager, T. ; Gabrielsen, A. ; Iversen, L. H. ; Kirkegaard, K.
  • Assuntos: Adult ; Assisted Reproduction Technologies ; Blastocyst - cytology ; Cell culture ; Culture media ; Culture Media - chemistry ; Embryo Culture Techniques - methods ; Embryo transfer ; Embryo Transfer - methods ; Embryos ; Female ; Fertilization in Vitro - methods ; Gynecology ; Human Genetics ; Humans ; Live Birth - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Retrospective Studies ; Sex Ratio ; Trophectoderm
  • É parte de: Journal of assisted reproduction and genetics, 2024-05, Vol.41 (5), p.1181-1191
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Purpose The purpose of this study was to provide a detailed analysis of clinical and laboratory factors associated with skewed secondary sex ratio (SSR) after ART. Method Retrospective cohort study of embryos resulting in live births, from frozen and fresh single blastocyst transfers. Embryos were cultured in either G-TL ( n  = 686) or Sage media ( n  = 685). Data was analyzed using a multivariate logistic regression model and a mixed model analysis. Results Significantly more male singletons were born after culture in Sage media compared to G-TL media (odds ratio (OR) 1.34, 95% CI (1.05, 1.70), P  = 0.02). Inner cell mass grade B vs A (OR 1.36 95% CI (1.05, 1.76), P  = 0.02) and one previous embryo transfer (OR 1.49, 95% CI (1.03, 2.16), P  = 0.03) were associated with a significantly higher probability of male child at birth. Factors associated with a reduced probability of male child were expansion grade 3 vs 5 (OR 0.66, 95% CI (10.45, 0.96), P  = 0.03) and trophectoderm grade B vs A (OR 0.57, 95% CI (0.44, 0.74), P  = 0.00). Male embryos developed significantly faster in Sage media compared to G-TL media for the stages of blastocyst (− 1.12 h, 95% CI (− 2.12, − 0.12)), expanded blastocyst (− 1.35 h, 95% CI (− 2.34, − 0.35)), and hatched blastocyst (− 1.75 h, 95% CI (− 2.99, − 0.52)). Conclusion More male children were born after culture in Sage media compared to G-TL media. Male embryo development was affected by culture media. Our observations suggest that culture media impact male embryo quality selectively, thus potentially favoring the selection of male embryos.
  • Editor: New York: Springer US
  • Idioma: Inglês
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