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Factors associated with Group A Streptococcus emm type diversification in a large urban setting in Brazil: a cross-sectional study

Tartof, Sara Y ; Reis, Joice N ; Andrade, Aurelio N ; Ramos, Regina T ; Reis, Mitermayer G ; Riley, Lee W

BMC infectious diseases, 2010-11, Vol.10 (1), p.327-327, Article 327 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Factors associated with Group A Streptococcus emm type diversification in a large urban setting in Brazil: a cross-sectional study
Autor: Tartof, Sara Y ; Reis, Joice N ; Andrade, Aurelio N ; Ramos, Regina T ; Reis, Mitermayer G ; Riley, Lee W
Assuntos: Adolescent ; Bacterial Typing Techniques ; Biological diversity ; Brazil - epidemiology ; Child ; Child, Preschool ; Clinics ; Cross-Sectional Studies ; Demographic aspects ; Disease ; Disease transmission ; Distribution ; Female ; Genetic aspects ; Genetic Variation ; Genotype ; Human subjects ; Humans ; Identification and classification ; Low income groups ; Male ; Medical research ; Pharyngitis ; Poverty Areas ; Public health ; Settlements & damages ; Socioeconomic factors ; Statistical analysis ; Streptococcal Infections - epidemiology ; Streptococcal Infections - microbiology ; Streptococcus ; Streptococcus pyogenes ; Streptococcus pyogenes - classification ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - isolation & purification ; Studies ; Urban Population
É parte de: BMC infectious diseases, 2010-11, Vol.10 (1), p.327-327, Article 327
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Group A Streptococcus (GAS) strain diversity varies across different regions of the world, according to low versus high-income countries. These differences may be related to geographic, environmental, socioeconomic, or host-related factors. However, local factors may also affect strain diversity. We compared the emm types of GAS isolates from children with and without sore throat in one large urban setting in Brazil. Children 3-15 years of age were consecutively recruited from slum and non-slum pediatric outpatient clinics between April-October, 2008. Throat cultures were performed and data intake forms were completed. GAS isolates were typed by emm sequencing. From 2194 children, 254 (12%) GAS isolates were obtained. Of 238 GAS isolates that were emm-typed, 61 unique emm types were identified. Simpson's diversity index of the emm types was higher among isolates from slum children [97% (96%-98%)] than those of non-slum children [92% (89%-96%)]. Two emm types (66.0, 12.0) were more frequently isolated from children with sore throat (p < 0.05), and one emm type (27G.0) demonstrated a protective effect. The emm type diversity from children attending slum clinics resembled the emm diversity of low income countries rather than that of children attending a non-slum clinic in the same city. Local factors, such as crowding, may enhance the frequency of GAS transmission and horizontal gene transfers that contribute to increased strain diversity in the slums. GAS vaccine coverage and control of GAS infections will need to take these local factors and strain differences into consideration.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Factors associated with Group A Streptococcus emm type diversification in a large urban setting in Brazil: a cross-sectional study

Tartof, Sara Y ; Reis, Joice N ; Andrade, Aurelio N ; Ramos, Regina T ; Reis, Mitermayer G ; Riley, Lee W

England: BioMed Central Ltd

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