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Safety of investigative bronchoscopy in the Severe Asthma Research Program

Moore, Wendy C., MD ; Evans, Michael D., MS ; Bleecker, Eugene R., MD ; Busse, William W., MD ; Calhoun, William J., MD ; Castro, Mario, MD ; Chung, Kian Fan, MD ; Erzurum, Serpil C., MD ; Curran-Everett, Douglas, PhD ; Dweik, Raed A., MD ; Gaston, Benjamin, MD ; Hew, Mark, MD ; Israel, Elliot, MD ; Mayse, Martin L., MD ; Pascual, Rodolfo M., MD ; Peters, Stephen P., MD, PhD ; Silveira, Lori, MS ; Wenzel, Sally E., MD ; Jarjour, Nizar N., MD

Journal of allergy and clinical immunology, 2011-08, Vol.128 (2), p.328-336.e3 [Periódico revisado por pares]

New York, NY: Mosby, Inc

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Título:
Safety of investigative bronchoscopy in the Severe Asthma Research Program
Autor: Moore, Wendy C., MD ; Evans, Michael D., MS ; Bleecker, Eugene R., MD ; Busse, William W., MD ; Calhoun, William J., MD ; Castro, Mario, MD ; Chung, Kian Fan, MD ; Erzurum, Serpil C., MD ; Curran-Everett, Douglas, PhD ; Dweik, Raed A., MD ; Gaston, Benjamin, MD ; Hew, Mark, MD ; Israel, Elliot, MD ; Mayse, Martin L., MD ; Pascual, Rodolfo M., MD ; Peters, Stephen P., MD, PhD ; Silveira, Lori, MS ; Wenzel, Sally E., MD ; Jarjour, Nizar N., MD
Assuntos: Adolescent ; Adult ; Allergy and Immunology ; Asthma ; Asthma - etiology ; Asthma - pathology ; Asthma - physiopathology ; Biological and medical sciences ; Biopsy ; Bronchi - pathology ; Bronchi - physiopathology ; Bronchial Provocation Tests ; Bronchoscopy - adverse effects ; Bronchoscopy - methods ; Chronic obstructive pulmonary disease ; Drug therapy ; Embolisms ; exacerbation ; Family medical history ; Female ; Forced Expiratory Volume ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Hospitalization ; Hospitals ; Humans ; Immunopathology ; Investigative bronchoscopy ; Male ; Medical sciences ; Pediatrics ; Respiratory Function Tests ; safety ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; severe asthma ; Severity of Illness Index ; Studies ; Young Adult
É parte de: Journal of allergy and clinical immunology, 2011-08, Vol.128 (2), p.328-336.e3
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The Severe Asthma Research Program (SARP) is a multicenter asthma research group funded by the NHLBI and consisting of the following contributors (Principal Investigators are marked with an asterisk)
Brigham & Women’s Hospital - Elliot Israel*, Bruce D. Levy, Gautham Marigowda, Michael E.Wechsler; Cleveland Clinic - Serpil C. Erzurum*, Raed A. Dweik, Suzy A.A. Comhair, Emmea Cleggett-Mattox, Deepa George, Marcelle Baaklini, Daniel Laskowski; Emory University - Anne M. Fitzpatrick, Denise Whitlock, Shanae Wakefield; Imperial College School of Medicine - Kian F. Chung*, Mark Hew, Patricia Macedo, Sally Meah, Florence Chow; University of Iowa – Eric Hoffman; University of Pittsburgh - Sally E. Wenzel*, Fernando Holgion, Jen Chamberlin; University of Texas-Medical Branch - William J. Calhoun*, Bill T. Ameredes; University of Virginia - Benjamin Gaston*, W. Gerald Teague*, Denise Thompson-Batt; University of Wisconsin - William W. Busse*, Nizar Jarjour, Ronald Sorkness, Sean Fain, Erin Billmeyer, Cheri Swenson, Gina Crisafi, Laura Frisque, Dan Polk; Wake Forest University - Eugene R. Bleecker*, Deborah Meyers, Wendy Moore, Stephen Peters, Rodolfo M. Pascual, Annette Hastie, Gregory Hawkins, Jeffrey Krings, Regina Smith; Washington University in St Louis - Mario Castro*, Leonard Bacharier, Jaime Tarsi; Data Coordinating Center - Douglas Curran-Everett*, Ruthie Knowles, Maura Robinson, Lori Silveira; NHLBI - Patricia Noel, Robert Smith
Descrição: Background Investigative bronchoscopy was performed in a subset of participants in the Severe Asthma Research Program to gain insights into the pathobiology of severe disease. We evaluated the safety aspects of this procedure in this cohort with specific focus on patients with severe asthma. Objective To evaluate prospectively changes in lung function and the frequency of adverse events related to investigative bronchoscopy. Methods Bronchoscopy was performed by using a common manual of procedures. A subset of very severe asthma was defined by severe airflow obstruction, chronic oral corticosteroid use, and recent asthma exacerbations. Subjects were monitored for changes in lung function and contacted by telephone for 3 days after the procedure. Results A total of 436 subjects underwent bronchoscopy (97 normal, 196 not severe, 102 severe, and 41 very severe asthma). Nine subjects were evaluated in hospital settings after bronchoscopy; 7 of these were respiratory-related events. Recent emergency department visits, chronic oral corticosteroid use, and a history of pneumonia were more frequent in subjects who had asthma exacerbations after bronchoscopy. The fall in FEV1 after bronchoscopy was similar in the severe and milder asthma groups. Prebronchodilator FEV1 was the strongest predictor of change in FEV1 after bronchoscopy with larger decreases observed in subjects with better lung function. Conclusion Bronchoscopy in subjects with severe asthma was well tolerated. Asthma exacerbations were rare, and reduction in pulmonary function after the procedure was similar to that in subjects with less severe asthma. With proper precautions, investigative bronchoscopy can be performed safely in severe asthma.
Editor: New York, NY: Mosby, Inc
Idioma: Inglês

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Safety of investigative bronchoscopy in the Severe Asthma Research Program

New York, NY: Mosby, Inc

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