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Safety of Intratympanic Injection of AM-101 in Patients with Acute Inner Ear Tinnitus

Muehlmeier, G. ; Biesinger, E. ; Maier, H.

Audiology & neurotology, 2011-09, Vol.16 (6), p.388-397 [Periódico revisado por pares]

Basel, Switzerland: Karger

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Título:
Safety of Intratympanic Injection of AM-101 in Patients with Acute Inner Ear Tinnitus
Autor: Muehlmeier, G. ; Biesinger, E. ; Maier, H.
Assuntos: Adolescent ; Adult ; Biological and medical sciences ; Clinical trials ; Cochlea - drug effects ; Double-Blind Method ; Drug therapy ; Ear diseases ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Excitatory Amino Acid Antagonists - administration & dosage ; Excitatory Amino Acid Antagonists - adverse effects ; Excitatory Amino Acid Antagonists - therapeutic use ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Original Paper ; Otorhinolaryngology. Stomatology ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Tinnitus ; Tinnitus - drug therapy ; Treatment Outcome ; Tympanic Membrane - drug effects
É parte de: Audiology & neurotology, 2011-09, Vol.16 (6), p.388-397
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
Descrição: Effective pharmacological treatments for tinnitus have proven elusive. Emerging evidence suggests that dysregulation of cochlear N-methyl-D-aspartate (NMDA) receptors may underlie aberrant excitation of the auditory nerve, which in turn is perceived as tinnitus. The blocking of these receptors thus represents a promising therapeutic approach. In a recent phase I/II clinical trial, the safety and local tolerance of intratympanic injections of the NMDA receptor antagonist AM-101 was evaluated for the first time in humans. The results from the double-blind, randomized, placebo-controlled study show that intratympanically injected AM-101 was well tolerated by study participants, and provided the first indications of therapeutic efficacy.
Editor: Basel, Switzerland: Karger
Idioma: Inglês

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Safety of Intratympanic Injection of AM-101 in Patients with Acute Inner Ear Tinnitus

Muehlmeier, G. ; Biesinger, E. ; Maier, H.

Basel, Switzerland: Karger

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