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Burn Injury Leads to Increased Long-Term Susceptibility to Respiratory Infection in both Mouse Models and Population Studies

Fear, Vanessa S ; Boyd, James H ; Rea, Suzanne ; Wood, Fiona M ; Duke, Janine M ; Fear, Mark W Huber, Victor C

PloS one, 2017-01, Vol.12 (1), p.e0169302-e0169302 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Burn Injury Leads to Increased Long-Term Susceptibility to Respiratory Infection in both Mouse Models and Population Studies
Autor: Fear, Vanessa S ; Boyd, James H ; Rea, Suzanne ; Wood, Fiona M ; Duke, Janine M ; Fear, Mark W
Huber, Victor C
Assuntos: Adult ; Analysis ; Animal models ; Animals ; Bacteria ; Biology and life sciences ; Burn patients ; Burns ; Burns - complications ; Burns and scalds ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Comorbidity ; Complications and side effects ; Correlation analysis ; Disease Models, Animal ; Disease Susceptibility ; Drainage ; Epidemiology ; Female ; Health aspects ; Health risks ; Health services ; Health Status ; Hospitalization ; Hospitals ; Humans ; Immune response ; Immune system ; Immunomodulation ; Incidence ; Infections ; Inflammation ; Inflammatory response ; Influenza ; Influenza A ; Influenza A virus ; Inhalation ; Injury prevention ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Lymph nodes ; Lymphocytes T ; Male ; Medicine and Health Sciences ; Mice ; Middle Aged ; Morbidity ; Mortality ; Natural killer cells ; Orthomyxoviridae ; Patient admissions ; Patients ; Pneumonia ; Population ; Population studies ; Population Surveillance ; Public health ; Research and Analysis Methods ; Respiration ; Respiratory tract ; Respiratory tract infection ; Respiratory tract infections ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - etiology ; Risk factors ; Sepsis ; Smoke ; Studies ; Surgery ; Survival analysis ; Viruses ; Western Australia - epidemiology ; Wound healing
É parte de: PloS one, 2017-01, Vol.12 (1), p.e0169302-e0169302
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: Regarding competing interests, the authors state that JD and MF received funding support from Woodside Coorporation and Chevron Australia. This funding was philanthropic funding provided to the Fiona wood foundation which is a non-profit health promotion charity that supports research into burn injury. The foundation used some of these funds to support researchers (JD and MF) involved in this study but there are no competing interests relating to this funding. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Conceptualization: VSF SR FMW JMD MWF.Data curation: JHB JMD.Formal analysis: VSF JHB JMD MWF.Funding acquisition: FMW JMD.Investigation: VSF JHB JMD.Methodology: VSF JHB JMD MWF.Project administration: VSF JMD FMW.Validation: JHB JMD.Visualization: VSF JMD MWF.Writing – original draft: VSF JMD MWF.Writing – review & editing: VSF JHB SR FMW JMD MWF.
Descrição: Burn injury initiates an acute inflammatory response that subsequently drives wound repair. However, acute disruption to the immune response is also common, leading to susceptibility to sepsis and increased morbidity and mortality. Despite increased understanding of the impact of burn injury on the immune system in the acute phase, little is known about long-term consequences of burn injury on immune function. This study was established to determine whether burn injury has long-term clinical impacts on patients' immune responses. Using a population-based retrospective longitudinal study and linked hospital morbidity and death data from Western Australia, comparative rates of hospitalisation for respiratory infections in burn patients and a non-injured comparator cohort were assessed. In addition, a mouse model of non-severe burn injury was also used in which viral respiratory infection was induced at 4 weeks post-injury using a mouse modified version of the Influenza A virus (H3NN; A/mem/71-a). The burn injured cohort contained 14893 adult patients from 1980-2012 after removal of those patients with evidence of smoke inhalation or injury to the respiratory tract. During the study follow-up study a total of 2,884 and 2,625 respiratory infection hospital admissions for the burn and uninjured cohorts, respectively, were identified. After adjusting for covariates, the burn cohort experienced significantly elevated admission rates for influenza and viral pneumonia (IRR, 95%CI: 1.73, 1.27-2.36), bacterial pneumonia (IRR, 95%CI: 2.05, 1.85-2.27) and for other types of upper and lower respiratory infections (IRR, 95% CI: 2.38, 2.09-2.71). In the mouse study an increased viral titre was observed after burn injury, accompanied by a reduced CD8 response and increased NK and NKT cells in the draining lymph nodes. This data suggests burn patients are at long-term increased risk of infection due to sustained modulation of the immune response.
Editor: United States: Public Library of Science
Idioma: Inglês

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Burn Injury Leads to Increased Long-Term Susceptibility to Respiratory Infection in both Mouse Models and Population Studies

Fear, Vanessa S ; Boyd, James H ; Rea, Suzanne ; Wood, Fiona M ; Duke, Janine M ; Fear, Mark W Huber, Victor C

United States: Public Library of Science

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