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Synthesis, characterization, and biological evaluation of Schiff base–platinum(II) complexes

Shiju, C. ; Arish, D. ; Bhuvanesh, N. ; Kumaresan, S.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015-06, Vol.145, p.213-222 [Periódico revisado por pares]

England: Elsevier B.V

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Título:
Synthesis, characterization, and biological evaluation of Schiff base–platinum(II) complexes
Autor: Shiju, C. ; Arish, D. ; Bhuvanesh, N. ; Kumaresan, S.
Assuntos: Anti-Infective Agents - pharmacology ; Anticancer ; Antimicrobial ; Antineoplastic Agents - pharmacology ; Antitubercular ; Antitubercular Agents - pharmacology ; Bacteria - drug effects ; Cell Proliferation - drug effects ; Coordination Complexes - chemical synthesis ; Coordination Complexes - chemistry ; Coordination Complexes - pharmacology ; Crystallography, X-Ray ; Fungi - drug effects ; HCT116 Cells ; HeLa Cells ; Humans ; Inhibitory Concentration 50 ; Ligands ; Microbial Sensitivity Tests ; Molecular Conformation ; Platinum - pharmacology ; Platinum complexes ; Powders ; Proton Magnetic Resonance Spectroscopy ; Schiff base ; Schiff Bases - chemical synthesis ; Schiff Bases - chemistry ; Schiff Bases - pharmacology ; Spectrophotometry, Infrared
É parte de: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2015-06, Vol.145, p.213-222
Descrição: [Display omitted] •The platinum complexes of Schiff base ligands were synthesized and characterized.•The structure of one of the ligands was confirmed by a single crystal XRD analysis.•The geometrical structures of these complexes are found to be square planar.•Antimicrobial studies indicate that these complexes exhibit better activity than the ligands.•[Pt(L3)Cl2] shows better activity towards M. tuberculosis H37Rv. The platinum complexes of Schiff base ligands derived from 4-aminoantipyrine and a few substituted aldehydes were synthesized and characterized by elemental analysis, mass, 1H NMR, IR, electronic spectra, molar conductance, and powder XRD. The structure of one of the ligands L5 was confirmed by a single crystal XRD analysis. The Schiff base ligand crystallized in the triclinic, space group P-1 with a=7.032(2)Ǻ, b=9.479(3)Ǻ, c=12.425(4)Ǻ, α=101.636(3)°, β=99.633(3)°, γ=94.040(3)°, V=795.0(4)Ǻ3, Z=2, F(000)=352, Dc=1.405mg/m3, μ=0.099mm−1, R=0.0378, and wR=0.0967. The spectral results show that the Schiff base ligand acts as a bidentate donor coordinating through the azomethine nitrogen and the carbonyl oxygen atoms. The geometrical structures of these complexes are found to be square planar. Antimicrobial studies indicate that these complexes exhibit better activity than the ligand. The anticancer activities of the complexes have also been studied towards human cervical cancer cell line (HeLa), Colon Cancer Cells (HCT116) and Epidermoid Carcinoma Cells (A431) and it was found that the [Pt(L3)Cl2] complex is more active.
Editor: England: Elsevier B.V
Idioma: Inglês

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Synthesis, characterization, and biological evaluation of Schiff base–platinum(II) complexes

Shiju, C. ; Arish, D. ; Bhuvanesh, N. ; Kumaresan, S.

England: Elsevier B.V

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