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Allergen Specific IgG Subclass Antibody Response in Hyposensitization with Dermatophagoides Pteronyssinus Extract

Pastorello, E A ; Incorvaia, C ; Gerosa, A ; Vassellatti, D ; Italia, M ; Pravettoni, V

Allergy and asthma proceedings, 1987-11, Vol.8 (6), p.417-421 [Periódico revisado por pares]

United States: OceanSide Publications, Inc

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Título:
Allergen Specific IgG Subclass Antibody Response in Hyposensitization with Dermatophagoides Pteronyssinus Extract
Autor: Pastorello, E A ; Incorvaia, C ; Gerosa, A ; Vassellatti, D ; Italia, M ; Pravettoni, V
Assuntos: Animals ; Antigen-Antibody Reactions ; Apis mellifera ; Child ; Dermatophagoides pteronyssinus ; Desensitization, Immunologic ; Double-Blind Method ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunoglobulin E - metabolism ; Immunoglobulin G - classification ; Immunoglobulin G - metabolism ; Mites - immunology ; Nasal Provocation Tests ; Random Allocation ; Rhinitis, Allergic, Perennial - immunology ; Rhinitis, Allergic, Perennial - therapy ; Skin Tests
É parte de: Allergy and asthma proceedings, 1987-11, Vol.8 (6), p.417-421
Notas: 1088-5412(19871101)8:6L.417;1-
(RF) Otorhinolaryngology
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Most of the controlled trials of specific immunotherapy (SIT) with house dust mite showed a good clinical efficacy of different kinds of extract after variable periods of treatment. However, few of them looked at all the parameters available to monitor this therapy, such as threshold dose of specific provocation test, end point titration and immunological variations.In particular, the behaviour of specific IgE antibodies is not completely known, while, in more recent studies, mite specific IgG antibodies have been shown to increase even in the early stages of treatment.Few data are available on mite specific IgG1-yy4 subclasses.The preliminary results of a double blind placebo controlled trial we performed with alginate conjugated Dermatophagoides pteronyssinus extract seem to indicate a good clinical and immunological response to this kind of extract.Moreover, we observed a significant increase of specific IgG antibodies, total and subclasses IgG1,2,4, with a prevalence of IgG4 subclass after three months of SIT.After two years of SIT mite specific IgG1 antibodies showed a tendency to decrease, while IgG4 antibodies maintained a constantly high level.These data suggest a restriction of IgG response to IgG4 subclass after prolonged mite specific immunotherapy, confirming previous similar results obtained in subjects with long lasting honey bee venom exposure.
Editor: United States: OceanSide Publications, Inc
Idioma: Inglês

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Allergen Specific IgG Subclass Antibody Response in Hyposensitization with Dermatophagoides Pteronyssinus Extract

Pastorello, E A ; Incorvaia, C ; Gerosa, A ; Vassellatti, D ; Italia, M ; Pravettoni, V

United States: OceanSide Publications, Inc

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