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Malignant renal neoplasms: correlation between ADC values and cellularity in diffusion weighted magnetic resonance imaging at 3 T

Manenti, G. ; Di Roma, M. ; Mancino, S. ; Bartolucci, D. A. ; Palmieri, G. ; Mastrangeli, R. ; Miano, R. ; Squillaci, E. ; Simonetti, G.

Radiologia medica, 2008-03, Vol.113 (2), p.199-213 [Periódico revisado por pares]

Milan: Springer Milan

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Título:
Malignant renal neoplasms: correlation between ADC values and cellularity in diffusion weighted magnetic resonance imaging at 3 T
Autor: Manenti, G. ; Di Roma, M. ; Mancino, S. ; Bartolucci, D. A. ; Palmieri, G. ; Mastrangeli, R. ; Miano, R. ; Squillaci, E. ; Simonetti, G.
Assuntos: Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell - diagnosis ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Case-Control Studies ; Contrast Media ; Diagnosis, Differential ; Diagnostic Radiology ; Diffusion ; Diffusion Magnetic Resonance Imaging - methods ; Diffusion Magnetic Resonance Imaging - standards ; Echo-Planar Imaging - methods ; Feasibility Studies ; Female ; Humans ; Imaging ; Interventional Radiology ; Kidney Neoplasms - diagnosis ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Linear Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasound ; Uro-Genital Radiology Radiologia Uro-Genitale
É parte de: Radiologia medica, 2008-03, Vol.113 (2), p.199-213
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SourceType-Scholarly Journals-1
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Descrição: Purpose This study aimed at exploring the feasibility of high-field diffusion-weighted magnetic resonance imaging (DW-MRI) (3 T) and to correlate apparent diffusion coefficient (ADC) values with tumour cellularity in renal malignancies. Materials and methods Thirty-seven patients (ten healthy volunteers and 27 patients with suspected renal malignancy) underwent T1-, T2-weighted and T1-weighted contrast-enhanced magnetic resonance imaging (MRI). Diffusion-weighted images were obtained with a single-shot spin-echo echo-planar imaging (SE-EPI) sequence with a b value of 500 s/mm 2 . All lesions were surgically resected, and mean tumour cellularity was calculated. Comparison between tumour cellularity and mean ADC value was performed using simple linear regression analysis. Results The mean ADC value in normal renal parenchyma was 2.35±0.31×10 −3 mm 2 /s, whereas mean ADC value in renal malignancies was 1.72±0.21×10 −3 mm 2 /s. In our population, there were no statistically significant differences between ADC values of different histological types. The analysis of mean ADC values showed an inverse linear correlation with cellularity in renal malignancies ( r =−0.73, p <0.01). Conclusions DW-MRI is able to differentiate between normal and neoplastic renal parenchyma on the basis of tissue cellularity.
Editor: Milan: Springer Milan
Idioma: Inglês;Italiano

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Malignant renal neoplasms: correlation between ADC values and cellularity in diffusion weighted magnetic resonance imaging at 3 T

Manenti, G. ; Di Roma, M. ; Mancino, S. ; Bartolucci, D. A. ; Palmieri, G. ; Mastrangeli, R. ; Miano, R. ; Squillaci, E. ; Simonetti, G.

Milan: Springer Milan

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