Idioma:

Interstitial PDT using diffuser fiber—investigation in phantom and in vivo models

Stringasci, Mirian D. ; Fortunato, Thereza C. ; Moriyama, Lilian T. ; Filho, José Dirceu Vollet ; Bagnato, Vanderlei S. ; Kurachi, Cristina

Lasers in medical science, 2017-07, Vol.32 (5), p.1009-1016 [Periódico revisado por pares]

London: Springer London

Texto completo disponível

Citações Citado por

Enviar para

Título:
Interstitial PDT using diffuser fiber—investigation in phantom and in vivo models
Autor: Stringasci, Mirian D. ; Fortunato, Thereza C. ; Moriyama, Lilian T. ; Filho, José Dirceu Vollet ; Bagnato, Vanderlei S. ; Kurachi, Cristina
Assuntos: Animals ; Asymmetry ; Cancer ; Dentistry ; Diffusers ; Emission ; Fiber optics ; Fibers ; Fluence ; Homogeneity ; Humans ; Illumination ; In vivo methods and tests ; Irradiation ; Lasers ; Light penetration ; Liver - pathology ; Liver - radiation effects ; Male ; Medicine ; Medicine & Public Health ; Models, Biological ; Necrosis ; Optical Devices ; Optical Fibers ; Optics ; Original Article ; Penetration ; Phantoms, Imaging ; Photochemotherapy - methods ; Photodynamic therapy ; Photonics ; Quantum Optics ; Radiation ; Rats, Wistar ; Solid tumors ; Tumors ; Variability
É parte de: Lasers in medical science, 2017-07, Vol.32 (5), p.1009-1016
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Photodynamic therapy (PDT) has been used for local treatment of several types of tumors. Light penetration of biological tissue is one limiting factor in PDT, decreasing the success rates of the treatment of invasive and solid tumors. In those cases, a possible solution is to use interstitial PDT, in which both diffuser optical fibers are inserted into the tumor. The uniformity of the diffuser emission plays a crucial role in planning the delivery of the appropriate light fluence and in ensuring treatment success. In this study, we characterized a diffuser optical fiber concerning its homogeneity. We showed that the diffuser emission can be inhomogeneous and that the necrosis generated by interstitial PDT using such a diffuser for illumination is asymmetrical in volume as a result. This observation has relevant consequences in achieving success in PDT and phototherapies in general, as the delivered light fluence depends on adequate previous knowledge of the irradiation profile.
Editor: London: Springer London
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 8 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Interstitial PDT using diffuser fiber—investigation in phantom and in vivo models

Stringasci, Mirian D. ; Fortunato, Thereza C. ; Moriyama, Lilian T. ; Filho, José Dirceu Vollet ; Bagnato, Vanderlei S. ; Kurachi, Cristina

London: Springer London

Buscando em bases de dados remotas. Favor aguardar.