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Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?

Mossello, Enrico ; Boncinelli, Marta ; Caleri, Veronica ; Cavallini, Maria Chiara ; Palermo, Eliana ; Di Bari, Mauro ; Tilli, Sabrina ; Sarcone, Eva ; Simoni, David ; Biagini, Carlo Adriano ; Masotti, Giulio ; Marchionni, Niccolò

Dementia and geriatric cognitive disorders, 2008-04, Vol.25 (4), p.372-379 [Periódico revisado por pares]

Basel, Switzerland: Karger

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Título:
Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?
Autor: Mossello, Enrico ; Boncinelli, Marta ; Caleri, Veronica ; Cavallini, Maria Chiara ; Palermo, Eliana ; Di Bari, Mauro ; Tilli, Sabrina ; Sarcone, Eva ; Simoni, David ; Biagini, Carlo Adriano ; Masotti, Giulio ; Marchionni, Niccolò
Assuntos: Aged ; Aged, 80 and over ; Alzheimer Disease - drug therapy ; Alzheimer Disease - psychology ; Antidepressive Agents - administration & dosage ; Biological and medical sciences ; Cardiovascular system ; Cognition - drug effects ; Cognition Disorders - drug therapy ; Cognition Disorders - psychology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depression - drug therapy ; Female ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Neurology ; Original Research Article ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Vasodilator agents. Cerebral vasodilators
É parte de: Dementia and geriatric cognitive disorders, 2008-04, Vol.25 (4), p.372-379
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background: Although antidepressant drugs (ATD) are frequently prescribed to patients with Alzheimer’s disease (AD), their effect on cognitive status has been only rarely assessed. Methods: The impact of depressive symptoms and ATD on cognitive status was retrospectively assessed in 72 older AD outpatients with mild-to-moderate cognitive impairment, treated with cholinesterase inhibitors, over a 9-month follow-up. Results: Compared to subjects without baseline depressive symptoms, those with symptoms who were continuously treated with ATD had less cognitive decline; those never treated, or not continuously treated despite baseline symptoms, had an intermediate trend. Such a protective action of ATD was, at least in part, independent of their action on depressive symptoms. Conclusion: These observations suggest that ATD may reduce cognitive decline in depressed older AD patients.
Editor: Basel, Switzerland: Karger
Idioma: Inglês

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Is Antidepressant Treatment Associated with Reduced Cognitive Decline in Alzheimer’s Disease?

Mossello, Enrico ; Boncinelli, Marta ; Caleri, Veronica ; Cavallini, Maria Chiara ; Palermo, Eliana ; Di Bari, Mauro ; Tilli, Sabrina ; Sarcone, Eva ; Simoni, David ; Biagini, Carlo Adriano ; Masotti, Giulio ; Marchionni, Niccolò

Basel, Switzerland: Karger

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