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Diabetes mellitus and inflammatory pulpal and periapical disease: a review

Lima, S. M. F. ; Grisi, D. C. ; Kogawa, E. M. ; Franco, O. L. ; Peixoto, V. C. ; Gonçalves-Júnior, J. F. ; Arruda, M. P. ; Rezende, T. M. B.

International endodontic journal, 2013-08, Vol.46 (8), p.700-709 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Diabetes mellitus and inflammatory pulpal and periapical disease: a review
  • Autor: Lima, S. M. F. ; Grisi, D. C. ; Kogawa, E. M. ; Franco, O. L. ; Peixoto, V. C. ; Gonçalves-Júnior, J. F. ; Arruda, M. P. ; Rezende, T. M. B.
  • Assuntos: Alveolar Bone Loss - complications ; apical periodontitis ; bone resorption ; Dentistry ; Diabetes Complications - blood ; Diabetes Complications - physiopathology ; diabetes mellitus ; Humans ; hyperglycaemia ; Hyperglycemia - complications ; osteoclastogenesis ; periapical periodontitis ; Periapical Periodontitis - complications ; Pulpitis - complications ; Risk Factors ; Root Canal Therapy
  • É parte de: International endodontic journal, 2013-08, Vol.46 (8), p.700-709
  • Notas: ArticleID:IEJ12072
    istex:B23BC6D4255B96788C5CD93779E6C78532088CF2
    ark:/67375/WNG-FV2V8HF2-8
    Universidade Católica de Brasília (UCB), Conselho Nacional de Desenvolvimento Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Fundação de Amparo do Distrito Federal (FAPDF)
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Diabetes mellitus (DM) is one of the most common metabolic disorders. DM is characterized by hyperglycaemia, resulting in wound healing difficulties and systemic and oral manifestations, which have a direct effect on dental pulp integrity. Experimental and clinical studies have demonstrated a higher prevalence of periapical lesions in patients with uncontrolled diabetes. The influence of DM on periapical bone resorption and its impact on dental intervention of such patients are reviewed, and its aetiology and pathogenesis are analysed at molecular level. Pulps from patients with diabetes have the tendency to present limited dental collateral circulation, impaired immune response, increased risk of acquiring pulp infection (especially anaerobic ones) or necrosis, besides toothache and occasional tendency towards pulp necrosis caused by ischaemia. In regard to molecular pathology, hyperglycaemia is a stimulus for bone resorption, inhibiting osteoblastic differentiation and reducing bone recovery. The relationship between poorly controlled diabetes and bone metabolism is not clearly understood. Molecular knowledge about pulp alterations in patients with diabetes could offer new therapeutic directions. Knowledge about how diabetes affects systemic and oral health has an enduring importance, because it may imply not only systemic complications but also a higher risk of oral diseases with a significant effect on pulp and periapical tissue.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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