Idioma:

Therapy‐related acute lymphoblastic leukemia is more frequent than previously recognized and has a poor prognosis

Abdulwahab, Amal ; Sykes, Jenna ; Kamel‐Reid, Suzanne ; Chang, Hong ; Brandwein, Joseph M.

Cancer, 2012-08, Vol.118 (16), p.3962-3967 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Texto completo disponível

Citações Citado por

Enviar para

Título:
Therapy‐related acute lymphoblastic leukemia is more frequent than previously recognized and has a poor prognosis
Autor: Abdulwahab, Amal ; Sykes, Jenna ; Kamel‐Reid, Suzanne ; Chang, Hong ; Brandwein, Joseph M.
Assuntos: acute lymphoblastic leukemia ; Adolescent ; Adult ; Aged ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; bone marrow transplantation ; chemotherapy ; chemotherapy complications ; Disease-Free Survival ; Female ; Hematologic and hematopoietic diseases ; Histone-Lysine N-Methyltransferase ; Humans ; leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Mutation ; Myeloid-Lymphoid Leukemia Protein - genetics ; Neoplasms, Radiation-Induced - mortality ; Neoplasms, Second Primary - etiology ; Neoplasms, Second Primary - mortality ; Neoplasms, Second Primary - therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Prognosis ; radiotherapy complications ; Tumors ; Young Adult
É parte de: Cancer, 2012-08, Vol.118 (16), p.3962-3967
Notas: Fax: (416) 946‐6546
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: BACKGROUND: Acute lymphoblastic leukemia (ALL) occurring in patients with a history of prior chemotherapy/radiotherapy exposure has been previously reported to be rare, accounting for <2.5% of ALL cases. METHODS: All cases of adult ALL with a history of prior cytotoxic or radiation therapy at a leukemia referral center over a 13‐year period were analyzed. RESULTS: Twenty‐three cases, representing 6.9% of all ALL cases, were identified. Of these, 17 (74%) had at least 1 high‐risk feature; 8 (35%) had MLL rearrangements, and 4 were BCR‐ABL+. MLL rearrangements were correlated with CD15 expression and absence of CD10, and also tended to have a shorter mean latency period and more prior topoisomerase II exposure. Twenty‐one patients received induction therapy, and 18 (86%) achieved a complete response, 17 with 1 induction. Six patients have relapsed and died, and 4 others died of other complications, 2 of these postallogeneic stem cell transplantation. Median disease‐free survival (DFS) and overall survival (OS) were 27 and 13.6 months, respectively, and 3‐year DFS and OS were 37.1% and 37.6%, respectively. CONCLUSIONS: The frequency of therapy‐related ALL is higher than previously reported and has a poor prognosis, probably related to the high frequency of adverse risk features. Cancer 2012. © 2011 American Cancer Society. Seven percent of adult acute lymphoblastic leukemia cases have received prior chemotherapy and/or radiotherapy. Nearly 80% have high‐risk features, most commonly MLL rearrangements, and overall prognosis is poor.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Therapy‐related acute lymphoblastic leukemia is more frequent than previously recognized and has a poor prognosis

Abdulwahab, Amal ; Sykes, Jenna ; Kamel‐Reid, Suzanne ; Chang, Hong ; Brandwein, Joseph M.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Buscando em bases de dados remotas. Favor aguardar.