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Remdesivir Treatment Lacks the Effect on Mortality Reduction in Hospitalized Adult COVID-19 Patients Who Required High-Flow Supplemental Oxygen or Invasive Mechanical Ventilation

Huang, Chienhsiu ; Lu, Tsung-Lung ; Lin, Lichen

Medicina (Kaunas, Lithuania), 2023-05, Vol.59 (6), p.1027 [Periódico revisado por pares]

Switzerland: MDPI AG

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  • Título:
    Remdesivir Treatment Lacks the Effect on Mortality Reduction in Hospitalized Adult COVID-19 Patients Who Required High-Flow Supplemental Oxygen or Invasive Mechanical Ventilation
  • Autor: Huang, Chienhsiu ; Lu, Tsung-Lung ; Lin, Lichen
  • Assuntos: Adults ; Analysis ; COVID-19 ; FDA approval ; hospital mortality ; Hospitalization ; Hospitals ; Infections ; Medical research ; Medicine, Experimental ; Mortality ; ordinal scale ; oxygen requirement ; remdesivir ; Review ; RNA polymerase ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis
  • É parte de: Medicina (Kaunas, Lithuania), 2023-05, Vol.59 (6), p.1027
  • Notas: SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    ObjectType-Review-1
    ObjectType-Article-3
  • Descrição: : The therapeutic impact of remdesivir on hospitalized adult COVID-19 patients is unknown. The purpose of this meta-analysis was to compare the mortality outcomes of hospitalized adult COVID-19 patients receiving remdesivir therapy to those of patients receiving a placebo based on their oxygen requirements. : The clinical status of the patients was assessed at the start of treatment using an ordinal scale. Studies comparing the mortality rate of hospitalized adults with COVID-19 treated with remdesivir vs. those treated with a placebo were included. : Nine studies were included and showed that the risk of mortality was reduced by 17% in patients treated with remdesivir. Hospitalized adult COVID-19 patients who did not require supplemental oxygen or who required low-flow oxygen and were treated with remdesivir had a lower mortality risk. In contrast, hospitalized adult patients who required high-flow supplemental oxygen or invasive mechanical ventilation did not have a therapeutic benefit in terms of mortality. : The clinical benefit of mortality reduction in hospitalized adult COVID-19 patients treated with remdesivir was associated with no need for supplemental oxygen or requiring supplemental low-flow oxygen at the start of treatment, especially in those requiring supplemental low-flow oxygen.
  • Editor: Switzerland: MDPI AG
  • Idioma: Inglês
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