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Pouteria macrophylla Fruit Extract Microemulsion for Cutaneous Depigmentation: Evaluation Using a 3D Pigmented Skin Model

Brathwaite, Ana Clara N. ; Alencar-Silva, Thuany ; Carvalho, Larissa A. C. ; Branquinho, Maryana S. F. ; Ferreira-Nunes, Ricardo ; Cunha-Filho, Marcilio ; Gelfuso, Guilherme M. ; Maria-Engler, Silvya S. ; Carvalho, Juliana Lott ; Silva, Joyce K. R. ; Gratieri, Tais

Molecules (Basel, Switzerland), 2022-09, Vol.27 (18), p.5982 [Periódico revisado por pares]

Basel: MDPI AG

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Título:
Pouteria macrophylla Fruit Extract Microemulsion for Cutaneous Depigmentation: Evaluation Using a 3D Pigmented Skin Model
Autor: Brathwaite, Ana Clara N. ; Alencar-Silva, Thuany ; Carvalho, Larissa A. C. ; Branquinho, Maryana S. F. ; Ferreira-Nunes, Ricardo ; Cunha-Filho, Marcilio ; Gelfuso, Guilherme M. ; Maria-Engler, Silvya S. ; Carvalho, Juliana Lott ; Silva, Joyce K. R. ; Gratieri, Tais
Assuntos: Cell culture ; Cell viability ; Cosmetics ; cutite extract ; Cytotoxicity ; Epidermis ; Fruits ; gallic acid ; Gene expression ; hyperpigmentation ; Irritation ; Melanin ; Melanocytes ; microemulsion ; Microemulsions ; Pouteria ; Skin ; Skin tests ; Surfactants ; Tyrosinase
É parte de: Molecules (Basel, Switzerland), 2022-09, Vol.27 (18), p.5982
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Here, we verify the depigmenting action of Pouteria macrophylla fruit extract (EXT), incorporate it into a safe topical microemulsion and assess its effectiveness in a 3D pigmented skin model. Melanocytes-B16F10- were used to assess the EXT effects on cell viability, melanin synthesis, and melanin synthesis-related gene transcription factor expression, which demonstrated a 32% and 50% reduction of intra and extracellular melanin content, respectively. The developed microemulsion was composed of Cremophor EL®/Span 80 4:1 (w/w), ethyl oleate, and pH 4.5 HEPES buffer and had an average droplet size of 40 nm (PdI 0.40 ± 0.07). Skin irritation test with reconstituted epidermis (Skin Ethic RHETM) showed that the formulation is non-irritating. Tyrosinase inhibition was maintained after skin permeation in vitro, in which microemulsion showed twice the inhibition of the conventional emulsion (20.7 ± 2.2% and 10.7 ± 2.4%, respectively). The depigmenting effect of the microemulsion was finally confirmed in a 3D culture model of pigmented skin, in which histological analysis showed a more pronounced effect than a commercial depigmenting formulation. In conclusion, the developed microemulsion is a promising safe formulation for the administration of cutite fruit extract, which showed remarkable depigmenting potential compared to a commercial formulation.
Editor: Basel: MDPI AG
Idioma: Inglês

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Pouteria macrophylla Fruit Extract Microemulsion for Cutaneous Depigmentation: Evaluation Using a 3D Pigmented Skin Model

Brathwaite, Ana Clara N. ; Alencar-Silva, Thuany ; Carvalho, Larissa A. C. ; Branquinho, Maryana S. F. ; Ferreira-Nunes, Ricardo ; Cunha-Filho, Marcilio ; Gelfuso, Guilherme M. ; Maria-Engler, Silvya S. ; Carvalho, Juliana Lott ; Silva, Joyce K. R. ; Gratieri, Tais

Basel: MDPI AG

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